Evidence map›Paper›PMID 39101627›Full record

ReviewAdvanced healthcare materials2024

Targeted Cancer Therapy-on-A-Chip.

Heba Abed, Remya Radha, Shabana Anjum, Vinod Paul, Nour AlSawaftah, William G Pitt, Nureddin Ashammakhi, Ghaleb A Husseini

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Deep Learning-Powered Scalable Cancer Organ Chip for Cancer Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Targeted Cancer Therapy-on-A-Chip.Advanced healthcare materials · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heba AbedDepartment of Chemical and Biological Engineering, American University of Sharjah, Sharjah, UAE.
Remya RadhaDepartment of Chemical and Biological Engineering, American University of Sharjah, Sharjah, UAE.
Shabana AnjumDepartment of Chemical and Biological Engineering, American University of Sharjah, Sharjah, UAE.
Vinod PaulMaterials Science and Engineering PhD program, College of Arts and Sciences, American University of Sharjah, Sharjah, UAE.
Nour AlSawaftahMaterials Science and Engineering PhD program, College of Arts and Sciences, American University of Sharjah, Sharjah, UAE.
William G PittDepartment of Chemical Engineering, Brigham Young University, Provo, UT, 84602, USA.
Nureddin AshammakhiInstitute for Quantitative Health Science and Engineering (IQ) and Department of Biomedical Engineering (BME), Michigan State University, East Lansing, MI, 48824, USA.ORCID 0000-0003-0181-6055
Ghaleb A HusseiniDepartment of Chemical and Biological Engineering, American University of Sharjah, Sharjah, UAE.ORCID 0000-0002-7244-3105

Funding

Al-Jalila Foundation AJF 2015555Al Qasimi Foundation, the Patient's Friends Committee-SharjahAmerican University of Sharjah Faculty Research Grants FRG20-L-E48 FRG22-C-E08Biosciences and Bioengineering Research Institute BBRI18-CEN-11Dana Gas Endowed Chair for Chemical EngineeringFriends of Cancer PatientsGCC Co-Fund Program IRF17-003Material Science and Engineering Ph.D. program at AUSSheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences MRG/18/2020Takamul Program P OC-00028-18Technology Innovation Pioneer MRG-57-2019-2020
6 · The paper itself

Abstract

Targeted cancer therapy (TCT) is gaining increased interest because it reduces the risks of adverse side effects by specifically treating tumor cells. TCT testing has traditionally been performed using two-dimensional (2D) cell culture and animal studies. Organ-on-a-chip (OoC) platforms have been developed to recapitulate cancer in vitro, as cancer-on-a-chip (CoC), and used for chemotherapeutics development and testing. This review explores the use of CoCs to both develop and test TCTs, with a focus on three main aspects, the use of CoCs to identify target biomarkers for TCT development, the use of CoCs to test free, un-encapsulated TCTs, and the use of CoCs to test encapsulated TCTs. Despite current challenges such as system scaling, and testing externally triggered TCTs, TCToC shows a promising future to serve as a supportive, pre-clinical platform to expedite TCT development and bench-to-bedside translation.

Indexed as

Lab-On-A-Chip DevicesNeoplasmsAnimalsAntineoplastic AgentsBiomarkers, TumorHumansAntineoplastic AgentsBiomarkers, Tumor3D culturechemotherapydrug deliverymicrofluidicorgan‐on‐a‐chiptargeting

Identifiers

PMID39101627
PMCPMC11582519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.