Evidence map›Paper›PMID 39101495›Full record

ArticleJournal of the American Heart Association2024

Outcomes and Predictors of Stroke After Transcatheter Aortic Valve Replacement in the Cerebral Protection Device Era.

Shashank Shekhar, Toshiaki Isogai, Ankit Agrawal, Roop Kaw, Gauranga Mahalwar, Amar Krishnaswamy, Rishi Puri, Grant Reed, Amgad Mentias, Samir Kapadia

Registry-linked trialAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07059728 (Uso de Lentillas de Alto Flujo en Procedimientos de sustitución de válvula aórtica transcatéter. Impacto en Las Complicaciones Respiratorias y Biomarcado- Res y Resultados clínicos. TAVR-Highflow), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07059728 narecruitingnot on this mapstarted 2025, after this paper: background citation

Uso de Lentillas de Alto Flujo en Procedimientos de sustitución de válvula aórtica transcatéter. Impacto en Las Complicaciones Respiratorias y Biomarcado- Res y Resultados clínicos. TAVR-Highflow

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2025 to 2027Enrolled452ConditionsAortic Stenosis Treated With TAVI, Sedation, Aged, HemodynamicsArmsOxygen therapy during sedation provided via high nasal cannulae (60L/min at 60% FiO2), Oxygen therapy during sedation delivered via nasal cannulae at 5L/min
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Remimazolam in the perioperative setting: an answer in search of an ideal question.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
  8. The NORTh Europe HOStile access TAVI (NORTHOSTAVI) registry.Frontiers in cardiovascular medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shashank ShekharDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-0615-425X
Toshiaki IsogaiDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-2172-6447
Ankit AgrawalDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-7885-6667
Roop KawDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-7712-7729
Gauranga MahalwarDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-5101-6024
Amar KrishnaswamyDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-6048-7955
Rishi PuriDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-8849-7426
Grant ReedDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-8234-3135
Amgad MentiasDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-6555-2517
Samir KapadiaDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-0026-3391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have shown inconclusive results on the effectiveness of cerebral protection devices (CPDs) with transcatheter aortic valve replacement. We aimed to analyze the national statistics on stroke and other outcomes with CPD use. METHODS AND

resultsThe Nationwide Readmissions Database (2017-2020) was queried to obtain data on patients undergoing transcatheter aortic valve replacement. Outcomes were compared between patients with a CPD and patients without a CPD. Of 271 804 patients undergoing transcatheter aortic valve replacement, CPD was used in 7.3% of patients. In a multivariable logistic regression analysis, CPD use was not associated with lower overall stroke rates (1.6% versus 1.9% without CPD; odds ratio, 0.95 [95% CI, 0.84-1.07];

conclusionsCPD use during transcatheter aortic valve replacement was not independently associated with a lower risk of overall stroke but was associated with a lower risk of major stroke in a multivariable model. Data from future randomized trials that may offset any potential confounders in our study are required to help identify patients who would benefit from the use of these devices.

Indexed as

StrokeTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAortic Valve StenosisDatabases, FactualEmbolic Protection DevicesFemaleHumansIncidenceMalePatient ReadmissionPostoperative ComplicationsRetrospective StudiesRisk AssessmentRisk Factorscerebral embolic protectionsentinel devicestrokeTAVR

Identifiers

PMID39101495
PMCPMC11964015

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.