Evidence map›Paper›PMID 39101490›Full record

ArticleCancer medicine2024

Systemic administration of Resolvin D1 reduces cancer-induced bone pain in mice: Lack of sex dependency in pain development and analgesia.

Alyssa Flippen, Iryna A Khasabova, Donald A Simone, Sergey G Khasabov

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Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alyssa FlippenDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
Iryna A KhasabovaDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
Donald A SimoneDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
Sergey G KhasabovDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4457-0294

Funding

Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signalingR01CA263777 · NCI · UNIVERSITY OF MINNESOTA · PI KHASABOV, SERGEY G · 2021 to 2025
$2.2M
Neural Mechanisms of Cancer PainR01CA241627 · NCI · UNIVERSITY OF MINNESOTA · PI SIMONE, DONALD · 2019 to 2023
$1.9M
NCI NIH HHS R01 CA241627NCI NIH HHS R01 CA263777NIH HHS CA241627NIH HHS CA263777
6 · The paper itself

Abstract

aimsBone cancer produces severe pain that is treated with opioids, but serious side effects limit opioid utilization. There is therefore a need to develop effective and safe non-opioid alternatives. The lipid mediator, Resolvin D1 (RvD1), could be a prospective candidate for cancer pain treatment. To assess RvD1 and other potential candidates, appropriate animal models that recapitulate clinical features must be used. Although several preclinical models of cancer pain have been developed, the influence of sex on the development of cancer pain and the effectiveness of RvD1 have not been studied.

resultsUsing a mouse model of fibrosarcoma growth in and around the calcaneus bone, we demonstrated that the mechanical hyperalgesia in the tumor-bearing hind paw develops independently of sex, except that it developed a little sooner in female mice. A single intravenous injection of RvD1 (0.001-10 μg/kg) decreased hyperalgesia in both sexes with similar potency (ED

conclusionIn this preclinical mouse model of bone cancer pain, the development of pain and the analgesic effectiveness of RvD1 are not influenced by sex.

Indexed as

Bone NeoplasmsCancer PainDisease Models, AnimalDocosahexaenoic AcidsHyperalgesiaAnalgesicsAnimalsFemaleFibrosarcomaMaleMicePain MeasurementSex FactorsAnalgesicsDocosahexaenoic Acidsresolvin D1antinociceptionbone cancer painmiceResolvin D1sex difference

Identifiers

PMID39101490
PMCPMC11299078

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.