Evidence map›Paper›PMID 39101435›Full record

ArticleFuture cardiology2024

A fatal case of cabozantinib-induced cardiomyopathy.

Sammudeen Ibrahim, Saint-Martin Allihien, Samuel Dadzie, Stanley E Atencah, Inemesit Akpan

Abstract readCase Reports
In one paragraph

Article in Future cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sammudeen IbrahimDepartment of Internal Medicine, Piedmont Athens Regional Medical Center, 1270 Prince Ave Athens, GA 30606, USA.ORCID 0009-0000-5039-8174
Saint-Martin AllihienDepartment of Internal Medicine, Piedmont Athens Regional Medical Center, 1270 Prince Ave Athens, GA 30606, USA.
Samuel DadzieDepartment of Internal Medicine, Piedmont Athens Regional Medical Center, 1270 Prince Ave Athens, GA 30606, USA.
Stanley E AtencahDepartment of Internal Medicine, Piedmont Athens Regional Medical Center, 1270 Prince Ave Athens, GA 30606, USA.
Inemesit AkpanDepartment of Internal Medicine, Piedmont Athens Regional Medical Center, 1270 Prince Ave Athens, GA 30606, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cabozantinib, a multi-kinase receptor inhibitor, is utilized in the treatment of advanced malignancies such as metastatic renal cancers. While rare, cabozantinib-induced cardiotoxicity has emerged as a recognized adverse effect with potentially reversible outcomes. We report the case of a 55-year-old male who developed fatal cardiomyopathy 4 months after initiating cabozantinib therapy. Despite its rarity, cardiomyopathy after initiation of cabozantinib can be lethal if not diagnosed early. This case underscores a significant gap in the surveillance of patients treated with newer agents like cabozantinib. Larger observational studies are needed to assess the prevalence and impact of cardiomyopathy after initiation of cabozantinib therapy, and to determine the cost-effectiveness of early surveillance protocols.

Indexed as

AnilidesCarcinoma, Renal CellCardiomyopathiesKidney NeoplasmsPyridinesAntineoplastic AgentsFatal OutcomeHumansMaleMiddle AgedProtein Kinase InhibitorsAnilidesAntineoplastic AgentscabozantinibProtein Kinase InhibitorsPyridinesCabozantinibcardiac dysfunctioncardiac monitoringcardiotoxicityheart failuretyrosine kinase inhibitors (TKIs)VEGFR inhibition

Identifiers

PMID39101435
PMCPMC11485716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.