Evidence map›Paper›PMID 39101338›Full record

ArticleActa dermato-venereologica2024

The Circadian Rhythm of Itching among 241 Adults with Atopic Dermatitis: A Cross-sectional Study.

Xiaoxue Sang, Jianyun Lu, Lina Tan, Jinrong Zeng, Dan Wang, Aiyuan Guo, Siyuan Tang, Qian Zeng, Wei Liu, Lihua Gao

Abstract read
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In one paragraph

Article in Acta dermato-venereologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoxue Sang *Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Jianyun Lu *The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Ozone Research Center of Central South University, Changsha, Hunan, China.
Lina TanThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Ozone Research Center of Central South University, Changsha, Hunan, China.
Jinrong ZengThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Ozone Research Center of Central South University, Changsha, Hunan, China.
Dan WangThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Ozone Research Center of Central South University, Changsha, Hunan, China.
Aiyuan GuoThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Ozone Research Center of Central South University, Changsha, Hunan, China.
Siyuan TangXiangya Nursing School, Central South University, Changsha, Hunan, China.
Qian ZengXiangya Nursing School, Central South University, Changsha, Hunan, China.
Wei LiuXiangya Nursing School, Central South University, Changsha, Hunan, China.
Lihua GaoThe Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Ozone Research Center of Central South University, Changsha, Hunan, China. 49516596@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pattern of itching in patients with atopic dermatitis has not been systematically studied. Therefore, this study aimed to assess the pattern of itching in adults with atopic dermatitis using questionnaires to assess for a circadian rhythm of itching in participating patients at a single institution (n = 241). A self-report questionnaire was used to assess circadian rhythm and intensity of itching in patients. In addition, the patients' disease severity (Eczema Area and Severity Index [EASI]) and quality of life (Dermatology Life Quality Index [DLQI]) were assessed. Itching occurred most frequently (74.69%) and with the greatest severity (62.66%) between 20:00 and 00:00, and the least number of patients (25.31%) experienced itching between 04:00 and 08:00. The DLQI and EASI scores both correlated with the average and maximum itch intensity (r = 0.582, r = 0.533, respectively; r = 0.539, r = 0.517, respectively; p < 0.001). The DLQI and EASI scores were associated with average itch intensity (B = 0.179, B = 0.204, respectively; 95% CI: 0.112 to 0.246, 95% CI: 0.096 to 0.313, respectively; p < 0.001), and the EASI score was associated with males and family history (B = 0.285, B = 0.287, respectively; 95% CI: 0.094 to 0.476, 95% CI: 0.096 to 0.478, respectively; p = 0.003). Adult patients with atopic dermatitis exhibited a circadian rhythm of itching; these study results could positively impact treatment approaches.

Indexed as

Circadian RhythmDermatitis, AtopicPruritusQuality of LifeSeverity of Illness IndexAdolescentAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedSelf ReportSurveys and QuestionnairesTime Factors

Identifiers

PMID39101338
PMCPMC11318504

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.