Evidence map›Paper›PMID 39101085›Full record

ArticleJournal of advanced veterinary and animal research2024

The effect of Andaliman (

Boyke Marthin Simbolon, O K Yulizal, Albert Manggading Hutapea, Erwin Handoko

Abstract read
In one paragraph

Article in Journal of advanced veterinary and animal research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Boyke Marthin SimbolonFaculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia.ORCID https://orcid.org/0009-0000-3447-7788
O K YulizalFaculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia.ORCID https://orcid.org/0000-0001-7916-9658
Albert Manggading HutapeaDepartment of Physiology, Universitas Advent Indonesi-a, Indonesia.ORCID https://orcid.org/0000-0003-4775-6107
Erwin HandokoQuality Assurance and Educational Development, Murni Teguh University, Deli Serdang, Indonesia.ORCID https://orcid.org/0000-0003-1414-0752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The present study investigated the effects of Andaliman fruit extract on tumor necrosis factor-alpha (TNF-α) and transient receptor potential ankyrin-1 (TRPA-1) levels in type 2 diabetes mellitus (T2DM) mouse models induced with streptozocin (STZ) and a high-fat diet (HFD). Materials and Methods: In this research, mice were allocated into six distinct groups: normal, negative control (HFD and STZ), positive control (metformin, HFD, and STZ), and three treatment groups (HFD, STZ, and Andaliman extract at varying dosages of 100, 300, and 500 mg/kg, respectively). Body weight and blood glucose levels (BGLs) were recorded at weeks 1 (baseline), 8, 12, and 16. The levels of TNF-α and TRPA-1 were measured during the 16th week. Results: Phytochemical screening of the Andaliman extract revealed the presence of flavonoids, alkaloids, tannins, saponins, and glycosides. The one-way ANOVA revealed significantly elevated BGL at week 16 in the negative control group in comparison to the other groups ( Conclusion: Andaliman extract potentially serves as a therapy for diabetic neuropathy in T2DM by lowering BGL and inhibiting the expression of TNF-α and TRPA-1.

Indexed as

Andaliman fruit extractTNF-αTRPA-1type 2 diabetes mellitusZanthoxylum acanthopodium fruit extract

Identifiers

PMID39101085
PMCPMC11296190

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.