Evidence map›Paper›PMID 39100673›Full record

ArticleFrontiers in immunology2024

A potent, broadly neutralizing human monoclonal antibody that efficiently protects hACE2-transgenic mice from infection with the Wuhan, BA.5, and XBB.1.5 SARS-CoV-2 variants.

Sergey V Guselnikov, Konstantin O Baranov, Sergey V Kulemzin, Tatyana N Belovezhets, Anton N Chikaev, Svetlana V Murasheva, Olga Y Volkova, Ludmila V Mechetina, Alexander M Najakshin, Nikolai A Chikaev and 13 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Sergey V Guselnikov *Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Konstantin O Baranov *Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Sergey V KulemzinInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Tatyana N BelovezhetsInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Anton N ChikaevInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Svetlana V MurashevaInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Olga Y VolkovaInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Ludmila V MechetinaInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Alexander M NajakshinInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Nikolai A ChikaevInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Pavel P SolodkovInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Maria V SergeevaDepartment of Vaccinology, Smorodintsev Research Institute of Influenza, Saint Petersburg, Russia.
Alexander V SmirnovInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Irina A SerovaInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Oleg L SerovInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Alexander G MarkhaevResearch Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Yulia V KononovaResearch Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Alexander Y AlekseevResearch Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Marina A GulyaevaResearch Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Daria M DanilenkoDepartment of Etiology and Epidemiology, Smorodintsev Research Institute of Influenza, Saint Petersburg, Russia.
Nariman R BattulinInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Alexander M ShestopalovResearch Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Alexander V TaraninInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has uncovered the high genetic variability of the SARS-CoV-2 virus and its ability to evade the immune responses that were induced by earlier viral variants. Only a few monoclonal antibodies that have been reported to date are capable of neutralizing a broad spectrum of SARS-CoV-2 variants. Here, we report the isolation of a new broadly neutralizing human monoclonal antibody, iC1. The antibody was identified through sorting the SARS-CoV-1 RBD-stained individual B cells that were isolated from the blood of a vaccinated donor following a breakthrough infection.

Indexed as

Angiotensin-Converting Enzyme 2Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19Mice, TransgenicSARS-CoV-2AnimalsBroadly Neutralizing AntibodiesDisease Models, AnimalHumansMicePandemicsSpike Glycoprotein, CoronavirusACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralBroadly Neutralizing AntibodiesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19iC1 antibodyin vivo protectionOmicronSARS-CoV-1

Identifiers

PMID39100673
PMCPMC11294225

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.