Evidence map›Paper›PMID 39100393›Full record

ArticleAdvanced engineering materials2024

Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing.

Ryan P Trueman, Owein Guillemot-Legris, Henry T Lancashire, Abijeet S Mehta, Joshua Tropp, Rachel E Daso, Jonathan Rivnay, Alethea B Tabor, James B Phillips, Bob C Schroeder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced engineering materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryan P TruemanUCL Centre for Nerve Engineering, University College London, London WC1N 1AX, UK; Department of Pharmacology, UCL School of Pharmacy, University College London, London WC1N 1AX, UK.
Owein Guillemot-LegrisUCL Centre for Nerve Engineering, University College London, London WC1N 1AX, UK, Department of Pharmacology, UCL School of Pharmacy, University College London, London WC1N 1AX, UK.
Henry T LancashireDepartment of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK.
Abijeet S MehtaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Joshua TroppDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Rachel E DasoDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Jonathan RivnayDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Alethea B TaborDepartment of Chemistry, University College London, London WC1H 0AJ, UK.
James B PhillipsUCL Centre for Nerve Engineering, University College London, London WC1N 1AX, UK, Department of Pharmacology, UCL School of Pharmacy, University College London, London WC1N 1AX, UK.
Bob C SchroederDepartment of Chemistry, University College London, London WC1H 0AJ, UK.

Funding

Regenerative Engineering Training Program (RE-Training)T32EB031527 · NIBIB · NORTHWESTERN UNIVERSITY · PI Guillermo Antonio Ameer · 2021 to 2026
$1.3M
NIBIB NIH HHS T32 EB031527
6 · The paper itself

Abstract

Electrical stimulation has shown promise in clinical studies to treat nerve injuries. This work is aimed to create an aligned bioelectronic construct that can be used to bridge a nerve gap, directly interfacing with the damaged nerve tissue to provide growth support. The conductive three-dimensional bioelectronic scaffolds described herein are composite materials, comprised of conductive polypyrrole (PPy) nanoparticles embedded in an aligned collagen hydrogel. The bioelectronic constructs are seeded with dorsal root ganglion derived primary rat neurons and electrically stimulated in vitro. The PPy loaded constructs support a 1.7-fold increase in neurite length in comparison to control collagen constructs. Furthermore, upon electrical stimulation of the PPy-collagen construct, a 1.8-fold increase in neurite length is shown. This work illustrates the potential of bioelectronic constructs in neural tissue engineering and lays the groundwork for the development of novel bioelectronic materials for neural interfacing applications.

Indexed as

bioelectronicsnerve repairneural engineeringpolypyrroletissue engineering

Identifiers

PMID39100393
PMCPMC11296654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.