Evidence map›Paper›PMID 39100344›Full record

ArticleACS omega2024

Insights into the Engineered Gold Nanoparticle-Based Remedy for Supplementation Therapy of Ovarian Carcinoma.

Muhammad Umar Farooq, Alexey P Dovzhenko, Rustem R Zairov, Gulmira Abyzbekova, Moussab Harb, Bassim Arkook, Nurgali Akylbekov, Anipa Tapalova, Mohamed M Makhlouf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad Umar FarooqSchool of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China.ORCID https://orcid.org/0000-0001-8804-9754
Alexey P DovzhenkoArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, Kazan 420088, Russian Federation.
Rustem R ZairovA. M. Butlerov Institute of Chemistry, Kazan Federal University, 1/29 Lobachevskogo str., Kazan 420008, Russian Federation.ORCID https://orcid.org/0000-0002-1699-6741
Gulmira AbyzbekovaDepartment of Biology, Geography and Chemistry, Korkyt Ata Kyzylorda University, Aiteke bi Str. 29A, Kyzylorda 120014, Kazakhstan.
Moussab HarbDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Bassim ArkookDepartment of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID https://orcid.org/0000-0002-4968-0954
Nurgali AkylbekovLaboratory of Engineering Profile "Physical and Chemical Methods of Analysis", Korkyt Ata Kyzylorda University, Aiteke bi Str. 29A, Kyzylorda 120014, Kazakhstan.ORCID https://orcid.org/0000-0002-7584-9741
Anipa TapalovaDepartment of Biology, Geography and Chemistry, Korkyt Ata Kyzylorda University, Aiteke bi Str. 29A, Kyzylorda 120014, Kazakhstan.
Mohamed M MakhloufDepartment of Sciences and Technology, Ranyah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID https://orcid.org/0000-0002-7413-4322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic diseases, notably cancer, pose a significant global threat to human life. Oncologists and medical professionals addressing malignancies confront challenges such as toxicity and multidrug resistance. To tackle these issues, the focus has shifted toward the employment of multifunctional colloidal gold nanoparticles. This study aims to design pH-sensitive doxorubicin-loaded gold nanoparticles using polyvinylpyrrolidone. The cytotoxic efficacy of the designed gold nanoarchitecture and its doxorubicin counterpart was assessed in an in vitro model using the HeLa cell. In comparison to the free drug, experimental evaluations showed that the gold nanoarchitecture outperformed significantly lower unspecific drug leaching and efficiently delivered the payload in a controlled manner, boosting the chemotherapy outcomes. This work opens a streamlined approach for engineering gold nanoarchitecture that could be further expanded to incorporate other therapeutics and/or functional moieties that require optimized controlled delivery, offering a one-size-fits-all solution and paving the revolutionary adjustments to healthcare procedures.

Identifiers

PMID39100344
PMCPMC11292810

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.