Evidence map›Paper›PMID 39100277›Full record

ArticleFrontiers in physiology2024

Subcutaneous advanced glycation end products, cardiovascular risk factors and vascular health during childhood development in a Swiss population.

Christoph Hauser, Giulia Lona, Sabrina Köchli, Lukas Streese, Denis Infanger, Oliver Faude, Henner Hanssen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christoph HauserDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Giulia LonaDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Sabrina KöchliDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Lukas StreeseDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Denis InfangerDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Oliver FaudeDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Henner HanssenDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Skin-derived advanced glycation end products (sAGEs) have been associated with cardiovascular (CV) risk and mortality in adults. We hypothesize that cardiorespiratory fitness (CRF), body mass index (BMI) and vascular health are associated with development of sAGEs during childhood. Methods: In our prospective cohort study, 1171 children aged 6-8 years were screened for sAGEs, BMI, retinal arteriolar diameters (CRAE) and pulse wave velocity (PWV), using standardized procedures. To determine CRF a 20 m shuttle run was performed. After four 4 years, all parameters were assessed in 675 children using the same protocols. Results: Higher initial CRF levels were significantly associated with lower sAGEs (β [95 CI] -0.02 [-0.03 to -0.002] au, Conclusion: Exercise and higher CRF may help mitigate the formation of AGEs during childhood, thereby reducing the risk for development of CV disease associated with AGEs-induced damage. Preventive strategies may need to target CRF early in life to achieve improvement of CV risk factors and may counteract the development of CV disease later in life.

Indexed as

advanced glycation end productschildhood cardiovascular riskprimary preventionpulse wave velocityretinal vessel diameters

Identifiers

PMID39100277
PMCPMC11294521

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.