Evidence map›Paper›PMID 39100099›Full record

ArticleFrontiers in cell and developmental biology2024

Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity.

Jacqueline F Machi, Isabella Altilio, Yue Qi, Alejo A Morales, Diego H Silvestre, Diana R Hernandez, Nicolas Da Costa-Santos, Aline G Santana, Mehrnoosh Neghabi, Parisa Nategh and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. c-Myc: an emerging participant in heart failure.Frontiers in cardiovascular medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jacqueline F MachiInterdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, United States.
Isabella AltilioInterdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, United States.
Yue QiInterdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, United States.
Alejo A MoralesInterdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, United States.
Diego H SilvestreDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL, United States.
Diana R HernandezDeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Nicolas Da Costa-SantosDepartment of Biomedical Science, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, United States.
Aline G SantanaDepartment of Biomedical Science, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, United States.
Mehrnoosh NeghabiDepartment of Electrical Engineering and Computer Science, College of Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL, United States.
Parisa NateghDepartment of Electrical Engineering and Computer Science, College of Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL, United States.
Thiago L CastroSchool of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.
João P Werneck-de-CastroDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL, United States.
Mahsa RanjiDepartment of Electrical Engineering and Computer Science, College of Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL, United States.
Fabiana S EvangelistaSchool of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.
Roberto I Vazquez-PadronDeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States.
Ernesto Bernal-MizrachiDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL, United States.
Claudia O RodriguesInterdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, United States.

Funding

A Novel Role for cMyc in Vascular HomeostasisR01HL128536 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RODRIGUES, CLAUDIA OLIVEIRA · 2017 to 2020
$1.8M
NHLBI NIH HHS R01 HL128536
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adiposityendothelial dysfunctionglucose intolerancemetabolismMYCobesity

Identifiers

PMID39100099
PMCPMC11294153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.