Evidence map›Paper›PMID 39099788›Full record

ArticleInternational journal of nanomedicine2024

Delivery of siRNAs Against Selective Ion Channels and Transporter Genes Using Hyaluronic Acid-coupled Carbonate Apatite Nanoparticles Synergistically Inhibits Growth and Survival of Breast Cancer Cells.

Mohammad Borhan Uddin, Mark M Banaszak Holl, Ezharul Hoque Chowdhury

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohammad Borhan UddinDepartment of Pharmaceutical Sciences, School of Health and Life Sciences, North South University, Dhaka, Bangladesh.ORCID 0000-0003-4384-4900
Mark M Banaszak HollDepartment of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-7759-7456
Ezharul Hoque ChowdhuryJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Selangor, 47500, Malaysia.ORCID 0000-0002-5705-841X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dysregulated calcium homeostasis and consequentially aberrant Ca Methods: Hybrid CA was synthesized by complexing CA NPs with a hydrophilic polysaccharide - hyaluronic acid (HA). The average diameter of the composite particles was determined using Zetasizer and FE-SEM and their zeta potential values were also measured. Results and Discussion: The stronger binding affinity and cellular uptake of a fluorescent siRNA were observed for HA-CA NPs as compared to plain CA NPs. Hybrid CA was electrostatically bound individually and combined with three different siRNAs to silence expression of calcium ion channel and transporter genes,

Indexed as

ApatitesBreast NeoplasmsHyaluronic AcidNanoparticlesRNA, Small InterferingAnimalsCell Line, TumorCell ProliferationCell SurvivalFemaleHumansMCF-7 CellsMiceApatitescarboapatiteHyaluronic AcidRNA, Small Interferingbreast cancercalcium ion channelcarbonate apatitecytotoxicityhyaluronic acidnanoparticlessiRNASLC41A1transporter genesTRPC6TRPM8

Identifiers

PMID39099788
PMCPMC11297548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.