Evidence map›Paper›PMID 39099759›Full record

ArticleBurns & trauma2024

Adipose stem cell-derived exosomes in the treatment of wound healing in preclinical animal models: a meta-analysis.

Jing-Tao Wei, Ting He, Kuo Shen, Zhi-Gang Xu, Jun-Tao Han, Xue-Kang Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing-Tao WeiDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, The First Affiliated Hospital of Air Force Medical University, Chang-Le Xi Street#127, Xi'an 710032, China.
Ting HeDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, The First Affiliated Hospital of Air Force Medical University, Chang-Le Xi Street#127, Xi'an 710032, China.ORCID https://orcid.org/0000-0002-3526-6656
Kuo ShenDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, The First Affiliated Hospital of Air Force Medical University, Chang-Le Xi Street#127, Xi'an 710032, China.ORCID https://orcid.org/0000-0002-8108-1951
Zhi-Gang XuDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, The First Affiliated Hospital of Air Force Medical University, Chang-Le Xi Street#127, Xi'an 710032, China.
Jun-Tao HanDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, The First Affiliated Hospital of Air Force Medical University, Chang-Le Xi Street#127, Xi'an 710032, China.
Xue-Kang YangDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, The First Affiliated Hospital of Air Force Medical University, Chang-Le Xi Street#127, Xi'an 710032, China.ORCID https://orcid.org/0009-0006-8550-3660

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Wound healing has always been a serious issue for doctors and primary health care systems. In addition, adipose stem cell-derived exosomes have been proven to play a positive and effective role in tissue repair and regeneration. A systematic review of these preclinical studies was performed to assess the efficacy of adipose stem cell-derived exosomes (ADSC-Exos) in treating wounds. This article aimed to study the effectiveness of ADSC-Exos for the treatment of animal skin wounds and includes a meta-analysis of exosomes from general wounds and diabetic ulcer wounds in Methods: A total of 19 studies with 356 animals were identified by searching the PubMed, Cochrane, MEDLINE Complete, Web of Science, CNKI and Wanfang databases from inception to 15 November 2022. No language or time restrictions were applied. Stata17 was used for all the data analyses. Results: The meta-analysis showed that ADSC-Exo therapy significantly improved the wound healing rate in the control group, except in the diabetes group on day 7. Day 7 of general wounds [standard mean difference (SMD) 2.87, 95% confidence interval (CI) 1.91-3.83)] and day 14 (SMD 2.89, 95%CI 1.47-4.30). Day 14 (SMD 3.43, 95%CI 1.28-5.58) of diabetic wounds. Other outcomes, such as blood vessel density, collagen deposition and wound re-epithelization, improved with the administration of ADSC-Exos. Conclusions: A meta-analysis showed that ADSC-Exo therapy applied to general and diabetic wounds can promote neovascularization, improve epithelization and collagen fiber deposition, promote healing, and reduce scar formation. ADSC-Exos have broad potential in preclinical research and clinical fields.

Indexed as

Adipose stem cellEpithelizationExosomesMeta-analysisNeovascularizationPreclinical studyScarWound healing

Identifiers

PMID39099759
PMCPMC11298109

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.