Article in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Min S KwonCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Hee K ChungCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Lan XiaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Ting-Xi YuCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Shweta SharmaCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Cassandra M CairnsCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-4364-4418
Ting ChenCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Songah ChaeCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Douglas J TurnerCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-5244-0417
Jian-Ying WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-3002-1040
Funding
Intestinal Mucosal Growth in Health & Surgical DiseasesR01DK057819 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2000 to 2026
$7.4M
Surgical Studies of Gut PermeabilityR01DK068491 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2004 to 2026
$7.0M
Mucosal Repair in Gut Surgical DisordersR01DK061972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING · 2002 to 2023
$6.7M
REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONI01BX000332 · VA · BALTIMORE VA MEDICAL CENTER · PI Jian-Ying Wang · 2009 to 2026
–
BLRD VA I01 BX000332HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK57819HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK61972HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK68491NIDDK NIH HHS R01 DK057819NIDDK NIH HHS R01 DK061972NIDDK NIH HHS R01 DK068491U.S. Department of Veterans Affairs (VA) 101BX000332
6 · The paper itself
Abstract
Paneth cells at the bottom of small intestinal crypts secrete antimicrobial peptides, enzymes, and growth factors and contribute to pathogen clearance and maintenance of the stem cell niche. Loss of Paneth cells and their dysfunction occur commonly in various pathologies, but the mechanism underlying the control of Paneth cell function remains largely unknown. Here, we identified microRNA-195 (miR-195) as a repressor of Paneth cell development and activity by altering SOX9 translation via interaction with RNA-binding protein HuR. Tissue-specific transgenic expression of miR-195 (miR195-Tg) in the intestinal epithelium decreased the levels of mucosal SOX9 and reduced the numbers of lysozyme-positive (Paneth) cells in mice. Ectopically expressed SOX9 in the intestinal organoids derived from miR-195-Tg mice restored Paneth cell development ex vivo. miR-195 did not bind to
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Interaction between microRNA-195 and HuR regulates Paneth cell function in the intestinal epithelium by altering SOX9 translation. · full record | OpenQuestion