Evidence map›Paper›PMID 39099388›Full record

ArticleBrain and behavior2024

Transcranial direct current stimulation over the right parietal cortex improves the depressive disorder: A preliminary study.

Xin Guo, Qilin Zhou, Yueying Lu, Zhexue Xu, Zhenye Wen, Ping Gu, Shujuan Tian, Yuping Wang

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Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

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5citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xin GuoDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Qilin ZhouDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yueying LuDepartment of Clinical Psychology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Zhexue XuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhenye WenDepartment of Rehabilitation, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Ping GuDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shujuan TianDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0009-0000-4160-5231
Yuping WangDepartment of Neurology, Hebei Hospital, Xuanwu Hospital, Capital Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0003-2488-5248

Funding

Hebei Province Government-funded Excellent Talents ZF2024147National Key Research and Development Program of China 2021YFC2501400National Key Research and Development Program of China 2021YFC2501404National Key Research and Development Program of China 2022YFC3600500National Key Research and Development Program of China 2022YFC3600503National Natural Science Foundation of China 82301458The Medical Science Research Project of Hebei Province 20230984The Medical Science Research Project of Hebei Province 20240529The Nature Science Foundation of Hebei Province H2024206372The Project of Traditional Chinese Medicine of Hebei Province 2023064The "Spark" scientific research project of the First Hospital of Hebei Medical University XH202314
6 · The paper itself

Abstract

objectiveThe right posterior parietal cortex is the core brain region of emotional processing and executive control network in the human brain, and the function of the right posterior parietal cortex is decreased in patients with major depressive disorder. This study aims to preliminarily investigate whether the excitation of the right posterior parietal cortex by transcranial direct current stimulation (tDCS) could improve their clinical symptoms.

methodsIn this study, 12 patients with major depressive disorder were given tDCS treatment at Xuanwu Hospital of Capital Medical University and the First Hospital of Hebei Medical University. The stimulating electrode (anode) was placed on the patients' right parietal cortex, whereas the reference electrode (cathode) was placed on the patients' left mastoid. The stimulation intensity was set as 2.0 mA. The patients with depressive disorder were treated for 20 min at a time twice a day for 14 consecutive days. The severity of the clinical symptoms was evaluated using the Hamilton Depression Rating Scale-17 (HDRS-17) and the Hamilton Anxiety Rating Scale (HARS) at before and right after treatment.

resultsThe HDRS-17 scores of patients with depressive disorder decreased significantly following the tDCS treatment compared with those before treatment (p < .001). Further analysis revealed that the patients' anxiety/somatization, cognitive deficit, retardation, and sleep disorder scores all decreased significantly after the tDCS treatment (p < .05), although there was no significant change in their weight. Moreover, the patients' HARS scores decreased significantly after the tDCS treatment when compared with those before treatment (p < .01).

conclusionThe right parietal cortex may be another key stimulation targets to improving the efficacy of tDCS treatment to the patients with major depressive disorder.

Indexed as

Major Depressive DisorderParietal LobeTranscranial Direct Current StimulationAdultFemaleHumansMaleMiddle AgedTreatment Outcomeanxietydepressionparietal cortextranscranial direct current stimulation

Identifiers

PMID39099388
PMCPMC11298686

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