Evidence map›Paper›PMID 39099235›Full record

ArticleRenal failure2024

Association between preoperative proton pump inhibitor use and postoperative acute kidney injury in patients undergoing major surgery.

Xizi Zheng, Qingqing Zhou, Yidan Zhu, Lingyi Xu, Damin Xu, Jicheng Lv, Li Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xizi ZhengRenal Division, Department of Medicine, Institute of Nephrology, Peking University First Hospital, Peking University, Beijing, China.
Qingqing ZhouRenal Division, Department of Medicine, Institute of Nephrology, Peking University First Hospital, Peking University, Beijing, China.
Yidan ZhuClinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, China.
Lingyi XuRenal Division, Department of Medicine, Institute of Nephrology, Peking University First Hospital, Peking University, Beijing, China.
Damin XuRenal Division, Department of Medicine, Institute of Nephrology, Peking University First Hospital, Peking University, Beijing, China.
Jicheng LvRenal Division, Department of Medicine, Institute of Nephrology, Peking University First Hospital, Peking University, Beijing, China.
Li YangRenal Division, Department of Medicine, Institute of Nephrology, Peking University First Hospital, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a severe postoperative complication in patients undergoing major surgery. Proton pump inhibitors (PPIs) are used preoperatively as prophylaxis for postoperative gastrointestinal bleeding. Whether preoperative PPI use is associated with an increased risk of postoperative AKI remains uncertain.

methodsThis retrospective cohort study used electronic medical records from the clinical data warehouse of Peking University First Hospital to screen all adult hospitalizations undergoing major surgery between 1 January 2018 and 31 December 2020. Exposure was preoperative PPI use, defined as PPI use within 7 days before major surgery. The primary outcome was postoperative AKI, defined as AKI occurring within 7 days after major surgery; secondary outcomes included in-hospital AKI and in-hospital mortality.

resultsA total of 21,533 patients were included in the study (mean [

conclusionsPreoperative PPI use was associated with an increased risk of AKI in patients undergoing major surgery. This risk may be enhanced by the concomitant use of other nephrotoxic drugs. Clinicians should weigh the pros and cons before initiating PPI prophylaxis.

Indexed as

Acute Kidney InjuryHospital MortalityPostoperative ComplicationsProton Pump InhibitorsAdultAgedChinaFemaleHumansMaleMiddle AgedPreoperative CareRetrospective StudiesRisk FactorsProton Pump Inhibitorsacute kidney injurymajor surgerymortalitynephrotoxicityProton pump inhibitor

Identifiers

PMID39099235
PMCPMC11302470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.