ArticleCommunications chemistry2024
Conjugated bis(enaminones) as effective templates for rotaxane assembly and their post-synthetic modifications.
Article in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Controlling cyclodextrin host-guest complexation in water with dynamic pericyclic chemistry.Communications chemistry · 2025Article
- Rotaxane synthesisRSC advances · 2025Article
- The catalyst-free green synthesis and QTAIM analysis of anilino-1,4-naphthoquinones as molecular wires.Scientific reports · 2025Article
- Design strategies and emerging applications for mechanically interlocked molecules.Communications chemistry · 2025Article
- Interlocking Pseudorotaxanes through Borane- and Boronic Ester-Mediated Carbon-Carbon Bond Formation.Organic letters · 2025Article
- A Thiourea-Based Rotaxane Catalyst: Nucleophilic Fluorination Phase-Transfer Process Unlocked by the Mechanical Bond.Organic letters · 2025Article
- A Redox-active Cyclometalated Platinum Ring Enables Synthetic Post-processing of a [2]Rotaxane.Angewandte Chemie (International ed. in English) · 2025Article
- Quinoline conjugates for enhanced antimalarial activity: a review on synthesis by molecular hybridization and structure-activity relationship (SAR) investigation.American journal of translational research · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The development of efficient methods for the synthesis of mechanically interlocked compounds is currently considered a major challenge in supramolecular chemistry. Twofold vinylogous fumaramides, a class of conjugated bis(enaminones), successfully achieve the assembly of hydrogen-bonded amide-based rotaxanes, with a templating ability comparable to that of their parent fumaramide-based systems, showcasing full conversions and impressive yields up to 92%. Computational calculations offer a compelling explanation for the remarkable efficiency of these bis(enaminones) in driving the synthesis of unprecedented rotaxanes. The reactivity of these interlocked species was thoroughly investigated, revealing that a one-step double stopper-exchange process can be successfully performed while preserving the mechanical bond. This approach facilitates the formation of controllable rotaxanes, including a three-station molecular shuttle, whose assembly via a clipping methodology is highly unselective. The internal translational motion of this latter species has been successfully controlled in a reversible way by means of a cycloaddition/retrocycloaddition sequence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.