ArticleClinics (Sao Paulo, Brazil)2024
Targeted saliva metabolomics in Sjögren's syndrome.
Article in Clinics (Sao Paulo, Brazil), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Hyposalivation Treatment with Non-Crosslinked Hyaluronic Acid and Amino Acids Solution-A Clinical Pilot Study.Life (Basel, Switzerland) · 2026Article
- Molecular Insights into Oral Manifestations in Sjögren's Disease.International journal of molecular sciences · 2026Review
- Structural and functional comparative analysis of porcine and human salivary glands: a narrative review for translational research.Journal of molecular histology · 2026Review
- Metabolite profiling of saliva for the discrimination of Behcet's disease, Sjögren's syndrome, and recurrent aphthous stomatitis.PloS one · 2026Article
- From subjective assessment to data-driven diagnosis: the AI revolution in multimodal early detection of Sjögren's disease.Frontiers in immunology · 2026Review
- Histone lactylation: a metabolic-epigenetic bridge linking glycolysis to salivary gland fibrosis in Sjögren's disease.Frontiers in immunology · 2026Review
- Salivary kynurenine pathway metabolites as potential non-invasive markers of glandular dysfunction in Sjögren's disease.Scientific reports · 2025Article
- Salivary Biomarkers for the Diagnosis of Sjögren's Syndrome: A Review of the Last Decade.Biomedicines · 2025Review
- Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases.MedComm · 2025Review
- Lipid Metabolism: An Emerging Player in Sjögren's Syndrome.Clinical reviews in allergy & immunology · 2025Review
- Shatai Heji Mitigates Sjögren Disease-Induced Xerostomia by Regulating AQP5, NF-κB, and p38 MAPK Signaling Pathwaysaff.Drug design, development and therapy · 2025Article
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Authors and funding
6 authors.
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Abstract
objectiveSjögren's Syndrome (SS) is a chronic inflammatory autoimmune exocrinopathy, and although, the role of metabolism in the autoimmune responses has been discussed in diseases such as lupus erythematosus, rheumatoid arthritis, psoriasis and scleroderma. There is a lack of information regarding the metabolic implications of SS. Considering that the disease affects primarily salivary glands; the aim of this study is to evaluate the metabolic changes in the salivary glands' microenvironment using a targeted metabolomics approach.
methodsThe saliva from 10 patients diagnosed with SS by the American-European consensus and 10 healthy volunteers was analyzed in an Ultra-high Performance Liquid Chromatograph Coupled Mass Spectrometry (UPLC-MS).
resultsThe results showed an increased concentration in SS of metabolites involved in oxidative stress such as lactate, alanine and malate, and amino acids involved in the growth and proliferation of T-cells, such as arginine, leucine valine and isoleucine.
conclusionsThese results revealed that is possible to differentiate the metabolic profile of SS and healthy individuals using a small amount of saliva, which in its turn may reflect the cellular changes observed in the microenvironments of damaged salivary glands from these patients.
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