Evidence map›Paper›PMID 39097716›Full record

ArticleAnnals of clinical microbiology and antimicrobials2024

Long-term successfull management of recurrent episodes of nontuberculous mycobacterial infection in an apparently healthy Chinese woman.

Angelo Roberto Raccagni, Giovanni Mori, Valeria Poletti de Chaurand, Raffaele Dell'Acqua, Daniela Maria Cirillo, Chiara Oltolini, Benedetta Mazzi, Francesco Scomazzoni, Antonella Castagna, Monica Guffanti

Abstract readCase Reports
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angelo Roberto RaccagniVita-Salute San Raffaele University, Via Stamira D'Ancona 20, Milano, 20127, Italy. raccagni.angelo@hsr.it.
Giovanni MoriVita-Salute San Raffaele University, Via Stamira D'Ancona 20, Milano, 20127, Italy.
Valeria Poletti de ChaurandEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Raffaele Dell'AcquaUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Daniela Maria CirilloVita-Salute San Raffaele University, Via Stamira D'Ancona 20, Milano, 20127, Italy.
Chiara OltoliniUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Benedetta MazziImmunogenetics Laboratory, Department of Immunohematology & Blood Transfusion, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesco ScomazzoniDepartment of Neuroradiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Antonella CastagnaVita-Salute San Raffaele University, Via Stamira D'Ancona 20, Milano, 20127, Italy.
Monica GuffantiUnit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisseminated non-tuberculous mycobacteria (dNTM) infections are mostly reported among individuals with an underlying congenital or acquired immunodeficiency or receiving immunosuppressive treatment, but are rarely documented in otherwise healthy subjects. CASE PRESENTATION: We describe a case of recurrent disseminated mycobacterial infection in an apparently immunocompetent Chinese woman. Mycobacterium szulgai and Mycobacterium avium-complex were identified in distinct episodes. Long-term antimycobacterial therapy was administered given the occurrence of recurrent events when off-treatment. Successful management over more than 10 years and immunologic data are reported.

conclusionsThis case-report highlights that dNTM should be suspected also among apparently immunocompetent hosts and that thorough assessment of underling immune-impairments is helpful to define patients' management. Long-term antimycobacterial therapy and close monitoring is required to grant successful outcomes in case of recurrent dNTM infections.

Indexed as

Mycobacterium Infections, NontuberculousNontuberculous MycobacteriaRecurrenceAdultAnti-Bacterial AgentsChinaEast Asian PeopleFemaleHumansMiddle AgedMycobacterium avium ComplexTreatment OutcomeAnti-Bacterial AgentsAntimycobacterial therapyIL-12/IFN-γ pathwayNontuberculous mycobacteria

Identifiers

PMID39097716
PMCPMC11298074

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.