Evidence map›Paper›PMID 39097697›Full record

ArticleCardiovascular diabetology2024

N-terminal pro-B-type natriuretic peptide levels vary by ethnicity and are associated with insulin sensitivity after gestational diabetes mellitus.

Archana Sharma, Kåre I Birkeland, Ingrid Nermoen, Christine Sommer, Elisabeth Qvigstad, Sindre Lee-Ødegård, Kari A Sveen, Naveed Sattar, Stina T Sollid, Torbjørn Omland and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Archana SharmaDepartment of Endocrinology, Akershus University Hospital, Lørenskog, Norway. archana.sharma@ahus.no.
Kåre I BirkelandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ingrid NermoenDepartment of Endocrinology, Akershus University Hospital, Lørenskog, Norway.
Christine SommerDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Elisabeth QvigstadInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sindre Lee-ØdegårdInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Kari A SveenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK.
Stina T SollidDepartment of Medicine, Drammen Hospital, Vestre Viken Health Trust, Drammen, Norway.
Torbjørn OmlandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Peder L MyhreInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals of South Asian origin have a greater risk of cardiovascular disease after gestational diabetes mellitus (GDM) than European individuals. B-type natriuretic peptide (BNP) and the amino-terminal fragment of its prohormone (NT-proBNP) are commonly used for heart failure screening and diagnosis, but biologically BNP exerts several beneficial cardiovascular effects primarily by counteracting the renin-angiotensin-aldosterone-system. We asked whether ethnic differences in circulating NT-proBNP levels could be explained by the differences in cardiometabolic and inflammatory risk markers?

methodsWe examined 162 South Asian and 107 Nordic women in Norway 1-3 years after GDM with a clinical examination, fasting blood samples and an oral glucose tolerance test. We measured the levels of NT-proBNP, high-sensitivity cardiac troponin T, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), leptin, adiponectin and markers of insulin sensitivity, such as the Matsuda insulin sensitivity index (ISI). Finally, we tried to identify which independent covariate best mediated the ethnic differences in NT-proBNP.

resultsThe mean (SD) age was 35.3 (4.5) years, BMI 29.1 (6.0) kg/m

conclusionsNT-proBNP levels are lower in South Asian than in Nordic women after GDM. Lower NT-proBNP levels correlate with impaired insulin sensitivity. Lower NT-proBNP levels in South Asian women could, therefore, be attributed to impaired insulin sensitivity rather than total body fat.

Indexed as

Diabetes, GestationalInsulin ResistanceNatriuretic Peptide, BrainPeptide FragmentsAdiponectinAdultBiomarkersBlood GlucoseCardiometabolic Risk FactorsEthnicityFemaleHumansInflammation MediatorsInsulinLeptinNorwayAdiponectinBiomarkersBlood GlucoseInflammation MediatorsInsulinLeptinNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)EthnicityGestational diabetes mellitusHeart diseaseInsulin sensitivityNormoglycemiaNT-proBNPPrediabetesPrevention

Identifiers

PMID39097697
PMCPMC11298077

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