Observational studyThe journals of gerontology. Series B, Psychological sciences and social sciences2024
Lifestyle, Cognitive, and Psychological Factors Associated With a Resilience Phenotype in Aging: A Multidimensional Approach on a Population-Based Sample of Oldest-Old (80+).
Observational study in The journals of gerontology. Series B, Psychological sciences and social sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01345110 (A Longitudinal Population Study on Brain Aging and Mental Performances for the 1935-1939 Born People Living in Abbiategrasso), which is not on this map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Longitudinal Population Study on Brain Aging and Mental Performances for the 1935-1939 Born People Living in Abbiategrasso (a Small Town Near Milan)
Who cites it
9 citing papers in PubMed.
- Pelvic Organ Prolapse Association with Iliopsoas Cross-Sectional Area and Muscle Strength in Middle-Aged and Older Women.International urogynecology journal · 2026Article
- A physically and mentally active lifestyle relates to younger brain and cognitive age.GeroScience · 2026Article
- Catastrophizing in Chronic Itch: Associations with Demographic, Clinical and Psychological Factors.Acta dermato-venereologica · 2026Article
- Development and validation of the LateDem-Risk score to predict dementia incidence in the InveCe.Ab and Trelong Italian cohorts.Scientific reports · 2026Article
- The interrelationships among insomnia, frailty, anxiety, and cognitive function in middle-aged and older adults: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Profiles of Aging Based on Cognition, Affect, and Brain Reserve.bioRxiv : the preprint server for biology · 2025Article
- A Multidimensional Perspective on Resilience in Later Life: A Systematic Literature Review of Protective Factors and Adaptive Processes in Ageing.Geriatrics (Basel, Switzerland) · 2025Review
- Cocota's Story: Life Lessons in Aging, Resilience, and End-of-Life Agency From a Brazilian Matriarch.Journal of the American Geriatrics Society · 2025Article
- Sex differences in health burdens across the lifespan in wild chimpanzees (Evolution, medicine, and public health · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the determinants of resilience phenotype in aging, operationalized as the maintenance of cognitive, physical, and psychological health in very old individuals (80+), we investigated the structure and interrelated impact of the main resilience-enhancing factors, which are usually studied in separate research fields.
methodsParticipants were older adults without dementia recruited for the fifth wave of the InveCe.Ab population-based cohort study (aged 83-87 years). Multidimensional evaluation comprised blood sampling, social and lifestyle survey, and geriatric and neuropsychological assessment. We classified resilient individuals as displaying normal cognition, functional independence, and mental health. First, we performed exploratory factor analysis (EFA) to examine the underlying structure of the relevant cognitive, lifestyle, physical, and psychological resilience-enhancing factors. The factors obtained were included as predictors of the resilience phenotype in the logistic regression model, controlling for sociodemographic and cumulative exposure to physical and psychosocial stressors, including COVID-19 infection.
resultsAmong the 404 enrolled participants, 153 (38%) exhibited the resilience phenotype. EFA resulted in the identification of six factors (59% of variance): cognitive reserve, affective reserve, insecure attachment, current lifestyle, physical reserve, and avoidant attachment. Among these factors, cognitive reserve, affective reserve, and current lifestyle significantly and independently predicted resilience status, controlling for cumulative exposure to age-related stressors and COVID-19 infection. DISCUSSION: Our findings showed that, even in very old age, both early and late life modifiable factors affect individuals' ability to adapt to the aging process, thus confirming the importance of a life-course approach to improve health outcomes in the aged population. CLINICAL TRIALS REGISTRATION NUMBER: NCT01345110.
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