Evidence map›Paper›PMID 39096127›Full record

ArticleJournal of neurotrauma2024

Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity.

Marija Markicevic, Francesca Mandino, Takuya Toyonaga, Zhengxin Cai, Arman Fesharaki-Zadeh, Xilin Shen, Stephen M Strittmatter, Evelyn M R Lake

Abstract read
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights.International journal of molecular sciences · 2025
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Marija MarkicevicDepartment of Radiology and Biomedical Imaging, School of Medicine, Yale University, New Haven, Connecticut, USA.ORCID 0000-0003-0983-432X
Francesca MandinoDepartment of Radiology and Biomedical Imaging, School of Medicine, Yale University, New Haven, Connecticut, USA.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, School of Medicine, Yale University, New Haven, Connecticut, USA.
Zhengxin CaiDepartment of Radiology and Biomedical Imaging, School of Medicine, Yale University, New Haven, Connecticut, USA.
Arman Fesharaki-ZadehDepartment of Neurology, School of Medicine, Yale University, New Haven, Connecticut, USA.
Xilin ShenDepartment of Radiology and Biomedical Imaging, School of Medicine, Yale University, New Haven, Connecticut, USA.
Stephen M StrittmatterDepartment of Neurology, School of Medicine, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-8188-3092
Evelyn M R LakeDepartment of Radiology and Biomedical Imaging, School of Medicine, Yale University, New Haven, Connecticut, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Prion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6M
Genome-Wide Discovery and Translational Research for Neural RepairR35NS097283 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2017 to 2024
$8.1M
SV2A PET in Spinal Cord Injury ImagingR01NS123183 · NINDS · YALE UNIVERSITY · PI Zhengxin Cai · 2022 to 2026
$3.3M
Multimodal imaging of prodromal synaptic, circuit, and network-level dysfunction in a murine model of Alzheimer's diseaseRF1NS130069 · NINDS · YALE UNIVERSITY · PI CAI, ZHENGXIN, LAKE, EVELYN MR · 2022 to 2022
$2.5M
Development of Novel SV2A PET Agents for Early Detection of Alzheimers DiseaseR01AG058773 · NIA · YALE UNIVERSITY · PI CAI, ZHENGXIN · 2018 to 2020
$2.4M
Synaptic selectivity for microglial-mediated damage in Alzheimer's DiseaseR01AG070926 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2024 to 2025
$1.6M
NCATS NIH HHS UL1 TR001863NIA NIH HHS P30 AG066508NIA NIH HHS R01 AG034924NIA NIH HHS R01 AG058773NIA NIH HHS R01 AG070926NINDS NIH HHS R01 NS123183NINDS NIH HHS R35 NS097283NINDS NIH HHS RF1 NS130069
6 · The paper itself

Abstract

Repeated mild head injuries due to sports, or domestic violence and military service are increasingly linked to debilitating symptoms in the long term. Although symptoms may take decades to manifest, potentially treatable neurobiological alterations must begin shortly after injury. Better means to diagnose and treat traumatic brain injuries requires an improved understanding of the mechanisms underlying progression and means through which they can be measured. Here, we employ a repetitive mild traumatic brain injury (rmTBI) and chronic variable stress mouse model to investigate emergent structural and functional brain abnormalities. Brain imaging is achieved with [

Indexed as

Brain ConcussionMagnetic Resonance ImagingSynapsesAnimalsMaleMiceMice, Inbred C57BLBOLD-fMRIclosed-head injuryregional homogeneitySV2A-PETsynapse loss

Identifiers

PMID39096127
PMCPMC11698675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.