Evidence map›Paper›PMID 39096036›Full record

ArticleJournal of anatomy2024

Cranial bone microarchitecture in a mouse model for syndromic craniosynostosis.

Sara Ajami, Zoe Van den Dam, Julia Hut, Dawn Savery, Milton Chin, Maarten Koudstaal, Miranda Steacy, Alessandra Carriero, Andrew Pitsillides, Y-M Chang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of anatomy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sara AjamiUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Zoe Van den DamUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Julia HutUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Dawn SaveryUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Milton ChinUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Maarten KoudstaalOral and Maxillofacial Department, Erasmus MC, Rotterdam, The Netherlands.
Miranda SteacyUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Alessandra CarrieroDepartment of Biomedical Engineering, The City College of New York, New York, NY, USA.
Andrew PitsillidesComparative Biomedical Sciences, The Royal Veterinary College, Royal College Street, London, UK.
Y-M ChangComparative Biomedical Sciences, The Royal Veterinary College, Royal College Street, London, UK.
Christoph RauDiamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.
Shashidhara MaratheDiamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.
David DunawayUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Noor Ul Owase JeelaniUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Silvia SchievanoUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Erwin PauwsUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Alessandro BorghiUCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-1514-1979

Funding

Biotechnology and Biological Sciences Research Council MR/R025673/1Diamond Light Source MG25386Diamond Light Source MG29093Great Ormond Street Hospital Charity 14DS25NIHR Great Ormond Street Hospital Biomedical Research Centre 17DS18
6 · The paper itself

Abstract

Crouzon syndrome is a congenital craniofacial disorder caused by mutations in the Fibroblast Growth Factor Receptor 2 (FGFR2). It is characterized by the premature fusion of cranial sutures, leading to a brachycephalic head shape, and midfacial hypoplasia. The aim of this study was to investigate the effect of the FGFR2 mutation on the microarchitecture of cranial bones at different stages of postnatal skull development, using the FGFR2

Indexed as

CraniosynostosesDisease Models, AnimalReceptor, Fibroblast Growth Factor, Type 2AnimalsCraniofacial DysostosisMiceSkullX-Ray MicrotomographyFgfr2 protein, mouseReceptor, Fibroblast Growth Factor, Type 2bonecraniofacialcraniosynostosisCrouzonFGFR2

Identifiers

PMID39096036
PMCPMC11547221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.