Evidence map›Paper›PMID 39096022›Full record

ArticleJournal of biological rhythms2024

Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice.

Olivia H Cox, Manuel A Giannoni-Guzmán, Jean-Philippe Cartailler, Matthew A Cottam, Douglas G McMahon

Erratum issuedAbstract read
In one paragraph

Article in Journal of biological rhythms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Circadian Genotypes in PER3 and Time of Prostate Cancer Radiotherapy Interact to Affect Risk of Late Side Effects.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  2. Article
  3. The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Olivia H CoxNeuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee.ORCID 0000-0002-0193-517X
Manuel A Giannoni-GuzmánDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee.
Jean-Philippe CartaillerThe Vanderbilt Creative Data Solutions Shared Resource, Vanderbilt University, Nashville, Tennessee.
Matthew A CottamThe Vanderbilt Creative Data Solutions Shared Resource, Vanderbilt University, Nashville, Tennessee.
Douglas G McMahonNeuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Photoperiodic Programming of Monoamine Brain CircuitsR01MH130537 · NIMH · VANDERBILT UNIVERSITY · PI Brad Alan Grueter, DOUGLAS G MCMAHON · 2023 to 2026
$2.6M
Neurobiology of the Circadian ClockR01GM117650 · NIGMS · VANDERBILT UNIVERSITY · PI MCMAHON, DOUGLAS G · 2015 to 2023
$2.1M
NICHD NIH HHS P50 HD103537NIGMS NIH HHS R01 GM117650NIMH NIH HHS R01 MH130537
6 · The paper itself

Abstract

Seasonal daylength, or circadian photoperiod, is a pervasive environmental signal that profoundly influences physiology and behavior. In mammals, the central circadian clock resides in the suprachiasmatic nuclei (SCN) of the hypothalamus where it receives retinal input and synchronizes, or entrains, organismal physiology and behavior to the prevailing light cycle. The process of entrainment induces sustained plasticity in the SCN, but the molecular mechanisms underlying SCN plasticity are incompletely understood. Entrainment to different photoperiods persistently alters the timing, waveform, period, and light resetting properties of the SCN clock and its driven rhythms. To elucidate novel candidate genes for molecular mechanisms of photoperiod plasticity, we performed RNA sequencing on whole SCN dissected from mice raised in long (light:dark [LD] 16:8) and short (LD 8:16) photoperiods. Fewer rhythmic genes were detected in mice subjected to long photoperiod, and in general, the timing of gene expression rhythms was advanced 4-6 h. However, a few genes showed significant delays, including

Indexed as

Circadian ClocksCircadian RhythmMelatoninPhotoperiodSuprachiasmatic NucleusTranscriptomeAnimalsMaleMiceMice, Inbred C57BLMelatonincircadianclockmousephotoperiodRNAseqsuprachiasmatic nucleus

Identifiers

PMID39096022
PMCPMC11425976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.