Evidence map›Paper›PMID 39095860›Full record

Trial reportBMC oral health2024

Evaluation of probiotics' efficiency on cariogenic bacteria: randomized controlled clinical study.

Didem Sakaryalı Uyar, Aylin Üsküdar Güçlü, Ekin Çelik, Betül Memiş Özgül, Aylin Altay Koçak, Ahmet Celal Başustaoğlu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05859646 (Evaluation of Streptococcus Mutans and Lactobacillus Species Due to Probiotic Use in Oral Flora), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05859646 nacompletednot on this map

Evaluation of Streptococcus Mutans and Lactobacillus Species Due to Probiotic Use in Oral Flora

TypeinterventionalSponsorDidem Sakaryali UyarRan2020 to 2022Enrolled58ConditionsTooth Decay, Probiotics, Streptococcus MutansArmsProbiotic use
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Effects of Oral Probiotics onDentistry journal · 2026
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Didem Sakaryalı UyarDepartment of Pediatric Dentistry, Faculty of Dentistry, Başkent University, Ankara, Türkiye. dsakaryali@baskent.edu.tr.ORCID http://orcid.org/0000-0001-7850-2375
Aylin Üsküdar GüçlüDepartment of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara, Türkiye.ORCID http://orcid.org/0000-0002-1872-028X
Ekin ÇelikDepartment of Medical Biology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir, Türkiye.ORCID http://orcid.org/0000-0003-1966-3907
Betül Memiş ÖzgülDepartment of Pediatric Dentistry, Faculty of Dentistry, Lokman Hekim University, Ankara, Türkiye.ORCID http://orcid.org/0000-0002-3291-6174
Aylin Altay KoçakDepartment of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara, Türkiye.ORCID http://orcid.org/0000-0002-0451-0142
Ahmet Celal BaşustaoğluDepartment of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara, Türkiye.ORCID http://orcid.org/0000-0002-2571-0637

Funding

Başkent University D-KA19/41
6 · The paper itself

Abstract

backgroundProbiotics are live beneficial bacteria to human health and their efficiency on oral health is still being investigated. The purpose of this study was to evaluate the level of Streptococcus mutans and Lactobacillus species with and without the use of probiotics for six-months after the treatment of all dental caries under general anesthesia.

methodsFifty-eight pediatric patients without any systemic diseases, whose dental treatments were completed under general anesthesia (GA), were included in the study. The patients were recruited in two-groups; Group A: Patients started using probiotics after GA and Group B: Patients did not use probiotics after GA. Saliva samples were taken from all patients on the day before GA (T0), at one-month (T1), three-month (T2) and six-month (T3) follow-up after GA. The counts of cariogenic bacteria were determined by the analysis of saliva samples using real-time polymerase chain reaction. Statistical significance level was accepted as p < 0.05.

resultsThere was statistically significant difference between Group A and B for T0, T1, T2 and T3 regarding S. mutans (p = 0.001, p = 0.04, p = 0.04, p = 0.03; p < 0.05). However, there was no statistically significant difference between groups regarding Lactobacillus species (p ≥ 0.05).

conclusionsProbiotic use and treatment of all caries significantly reduced the level of S. mutans but not Lactobacillus species. Furthermore, S. mutans decreased after cessation of probiotics, but it was not statistically significant.

trial registrationStudy was registered as "Effects of Probiotics on Streptococcus mutans and Lactobacillus species" with the registration number of NCT05859646 (16/05/2023) at https://www. CLINICALTRIALS: gov Protocol Registration and Results System.

Indexed as

Dental CariesLactobacillusProbioticsSalivaStreptococcus mutansAnesthesia, GeneralChildChild, PreschoolFemaleHumansMaleReal-Time Polymerase Chain ReactionDental cariesLactobacillus speciesOral floraProbioticsStreptococcus mutans

Identifiers

PMID39095860
PMCPMC11297621

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.