Evidence map›Paper›PMID 39095798›Full record

ReviewRespiratory research2024

G

Elizabeth L McDuffie, Reynold A Panettieri, Charles P Scott

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Correction to: GRespiratory research · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Elizabeth L McDuffieDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Reynold A PanettieriRutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, NJ, USA.
Charles P ScottDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. charles.scott@jefferson.edu.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LIGGETT, STEPHEN B · 2013 to 2023
$23.9M
NCATS NIH HHS UL1 TR003017NCATS NIH HHS UL1TR003017NHLBI NIH HHS HL114471NHLBI NIH HHS HL114471-S1NHLBI NIH HHS P01 HL114471NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for asthma. Airway shortening occurs through calcium-dependent activation of myosin light chain kinase, and RhoA-dependent calcium sensitization, which inhibits myosin light chain phosphatase. The mechanism through which pro-contractile stimuli activate calcium sensitization is poorly understood. Our review of the literature suggests that pro-contractile G protein coupled receptors likely signal through G

Indexed as

AsthmaSignal TransductionAirway RemodelingAnimalsGTP-Binding Protein alpha Subunits, G12-G13HumansMuscle, SmoothGTP-Binding Protein alpha Subunits, G12-G13Airway hyperresponsivenessAirway remodelingAnticholinergic agentsAsthmaBronchoconstrictionCalcium sensitizationG12/13InflammationMuscarinic 3 acetylcholine receptorRhoA

Identifiers

PMID39095798
PMCPMC11297630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.