Evidence map›Paper›PMID 39095775›Full record

ArticleJournal of neuroinflammation2024

CD44 signaling in Müller cells impacts photoreceptor function and survival in healthy and diseased retinas.

Monika Ayten, Tobias Straub, Lew Kaplan, Stefanie M Hauck, Antje Grosche, Susanne F Koch

Abstract read
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Monika AytenDepartment of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, 81377, Germany.
Tobias StraubBioinformatics Unit, Biomedical Center Munich, Ludwig-Maximilians-Universität München, Planegg-Martinsried, 82152, Germany.
Lew KaplanDepartment of Physiological Genomics, Biomedical Center Munich, Ludwig-Maximilians-Universität München, Planegg-Martinsried, 82152, Germany.
Stefanie M HauckMetabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Antje GroscheDepartment of Physiological Genomics, Biomedical Center Munich, Ludwig-Maximilians-Universität München, Planegg-Martinsried, 82152, Germany.
Susanne F KochDepartment of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, 81377, Germany. Susanne.Koch@cup.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinitis pigmentosa (RP), an inherited retinal disease, affects 1,5 million people worldwide. The initial mutation-driven photoreceptor degeneration leads to chronic inflammation, characterized by Müller cell activation and upregulation of CD44. CD44 is a cell surface transmembrane glycoprotein and the primary receptor for hyaluronic acid. It is involved in many pathological processes, but little is known about CD44's retinal functions. CD44 expression is also increased in Müller cells from our Pde6b

Indexed as

Ependymoglial CellsHyaluronan ReceptorsRetinitis PigmentosaSignal TransductionAnimalsCell SurvivalMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPhotoreceptor Cells, VertebrateRetinaCd44 protein, mouseHyaluronan ReceptorsCD44GliosisGlutamateInflammationMüller cellsRetinitis pigmentosaSLC1A2

Identifiers

PMID39095775
PMCPMC11297696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.