Evidence map›Paper›PMID 39095743›Full record

ArticleBMC cancer2024

FAM65A promotes the progression and growth of lung squamous cell carcinoma in vivo and vitro.

Fangjun Chen, Peng Ren, Rui Xu, Jin Zhang, Chaoyang Liang, Guangliang Qiang

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangjun ChenDepartment of Thoracic Surgery, Chine-Japan Friendship Institute of Clinical Medicine, Beijing, China.
Peng RenDepartment of Thoracic Surgery, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing, 100191, China.
Rui XuDepartment of Nuclear Medicine, Chine-Japan Friendship Hospital, Beijing, China.
Jin ZhangDepartment of Thoracic Surgery, Chine-Japan Friendship Hospital, Beijing, China.
Chaoyang LiangDepartment of Thoracic Surgery, Chine-Japan Friendship Hospital, Beijing, China.
Guangliang QiangDepartment of Thoracic Surgery, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing, 100191, China. pkudd@126.com.

Funding

Fundamental Research Funds for the Central Universities 3332020078Key Clinical Projects of Peking University Third Hospital BYSYRCYJ2023001
6 · The paper itself

Abstract

backgroundsCurrently, family with sequence similarity 65 member A (FAM65A) is reported as a pivotal regulator in various cancers. However, the effect of FAM65A in lung squamous cell carcinoma (LSCC) is still unclear, the prime objective of this research is to explore the role of FAM65A in LSCC.

methodsGene expression data and correlated clinical information were downloaded from the public database and the expression of FAM65A was detected. The expression of FAM65A was also detected in our collected clinical samples and LSCC cell lines. Survival package of R language was used to determine the survival significance of FAM65A. Proteins expression level was determined via western blot assay. Cell function experiments and in vivo experiments were performed to explore the effect of FAM65A on LSCC cell biological behaviors.

resultsFAM65A expression was significantly increased in LSCC clinical samples and cell lines. High FAM65A expression predicted poor prognosis in LSCC patients. After silencing FAM65A, the ability of LSCC cell proliferation, invasion and migration was decreased, and LSCC cell cycle was blocked. Moreover, in vivo experiments revealed that silencing FAM65A could inhibit LSCC cell proliferation.

conclusionsHigh FAM65A expression could enhance proliferative, invasive and migratory abilities of LSCC. FAM65A might be a novel biomarker of LSCC.

Indexed as

Carcinoma, Squamous CellIntracellular Signaling Peptides and ProteinsLung NeoplasmsAnimalsCell CycleCell Line, TumorCell ProliferationDisease ProgressionFemaleHumansMaleMiceMice, Inbred BALB CMiddle AgedProtein Interaction MapsIntracellular Signaling Peptides and ProteinsRIPOR1 protein, humanFAM65AInvasionLung squamous cell carcinomaMetastasisProliferation

Identifiers

PMID39095743
PMCPMC11295694

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