ArticleBMC microbiology2024
Low-dose zinc oxide nanoparticles trigger the growth and biofilm formation of Pseudomonas aeruginosa: a hormetic response.
Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Antimicrobial Systems Based on Essential Oils Advanced by Zinc Oxide Nanoparticles.ACS pharmacology & translational science · 2026Review
- One-pot fabrication and characterization of ZnO nanoflowers using Zanthoxylum simulans and evaluating their biomedical claims.Mikrochimica acta · 2026Article
- Effects of Lysozyme and Silver Anode Treatment on Pseudomonas aeruginosa Growth and Biofilm Formation in Raw Milk.Journal of food science · 2026Article
- Enhancing the yield and berry color of crimson seedless table grape variety (Vitis vinifera L.) via zinc oxide nanoparticles integrated with molasses.BMC plant biology · 2026Article
- Optimized green zinc oxide/chitosan/amoxicillin nanocomposite against Pseudomonas aeruginosa.Applied microbiology and biotechnology · 2026Article
- Interactions of microbial biofilms with metal nanoparticles in the context of bioremediation.Folia microbiologica · 2026Review
- UnderstandingMicroorganisms · 2026Review
- Broadly Defined Antibiotic Adjuvants forThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Review
- Phytochemical Composition and In Vitro Antibacterial Activity of the Essential Oil fromACS omega · 2025Article
- Biofilm-dispersal patterns in ESKAPE pathogens.Archives of microbiology · 2025Review
- Insights on Zosteric Acid Analogues Activity Against Candida albicans Biofilm Formation.ACS omega · 2025Article
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8 authors.
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Abstract
introductionHormesis describes an inverse dose-response relationship, whereby a high dose of a toxic compound is inhibitory, and a low dose is stimulatory. This study explores the hormetic response of low concentrations of zinc oxide nanoparticles (ZnO NPs) toward Pseudomonas aeruginosa.
methodSamples of P. aeruginosa, i.e. the reference strain, ATCC 27,853, together with six strains recovered from patients with cystic fibrosis, were exposed to ten decreasing ZnO NPs doses (0.78-400 µg/mL). The ZnO NPs were manufactured from Peganum harmala using a chemical green synthesis approach, and their properties were verified utilizing X-ray diffraction and scanning electron microscopy. A microtiter plate technique was employed to investigate the impact of ZnO NPs on the growth, biofilm formation and metabolic activity of P. aeruginosa. Real-time polymerase chain reactions were performed to determine the effect of ZnO NPs on the expression of seven biofilm-encoding genes.
resultThe ZnO NPs demonstrated concentration-dependent bactericidal and antibiofilm efficiency at concentrations of 100-400 µg/mL. However, growth was significantly stimulated at ZnO NPs concentration of 25 µg/mL (ATCC 27853, Pa 3 and Pa 4) and at 12.5 µg/mL and 6.25 µg/mL (ATCC 27853, Pa 2, Pa 4 and Pa 5). No significant positive growth was detected at dilutions < 6.25 µg/mL. similarly, biofilm formation was stimulated at concentration of 12.5 µg/mL (ATCC 27853 and Pa 1) and at 6.25 µg/mL (Pa 4). At concentration of 12.5 µg/mL, ZnO NPs upregulated the expression of LasB ( ATCC 27853, Pa 1 and Pa 4) and LasR and LasI (ATCC 27853 and Pa 1) as well as RhII expression (ATCC 27853, Pa 2 and Pa 4).
conclusionWhen exposed to low ZnO NPs concentrations, P. aeruginosa behaves in a hormetic manner, undergoing positive growth and biofilm formation. These results highlight the importance of understanding the response of P. aeruginosa following exposure to low ZnO NPs concentrations.
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