Evidence map›Paper›PMID 39095728›Full record

ArticleBMC microbiology2024

Effects of berberine hydrochloride on antioxidant response and gut microflora in the Charybdis japonica infected with Aeromonas hydrophila.

Mingming Han, Yanxia Guo, ShengKai Tang, Daming Li, Jinjuan Wan, Chenxi Zhu, Zakaria Zuraini, Ji Liang, Tianheng Gao, Zihan Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingming HanCentre for Marine and Coastal Studies, University Sains Malaysia, Minden, 11800, Malaysia.
Yanxia GuoFreshwater Fisheries Research Institute of Jiangsu, 79 Chating East Street, 210017, Nanjing, China.
ShengKai TangFreshwater Fisheries Research Institute of Jiangsu, 79 Chating East Street, 210017, Nanjing, China.
Daming LiFreshwater Fisheries Research Institute of Jiangsu, 79 Chating East Street, 210017, Nanjing, China.
Jinjuan WanFreshwater Fisheries Research Institute of Jiangsu, 79 Chating East Street, 210017, Nanjing, China.
Chenxi ZhuFreshwater Fisheries Research Institute of Jiangsu, 79 Chating East Street, 210017, Nanjing, China.
Zakaria ZurainiBiology Program, School of Distance Education, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia.
Ji LiangCentre for Marine and Coastal Studies, University Sains Malaysia, Minden, 11800, Malaysia.
Tianheng GaoInstitute of Marine Biology, College of Oceanography, Hohai University, 210024, Nanjing, China.
Zihan ZhouFreshwater Fisheries Research Institute of Jiangsu, 79 Chating East Street, 210017, Nanjing, China.
Qichen JiangCentre for Marine and Coastal Studies, University Sains Malaysia, Minden, 11800, Malaysia. qichenjiang@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study used berberine hydrochloride to treat the Asian paddle crab, Charybdis japonica infected with the Gram-negative bacterium Aeromonas hydrophila at concentrations of 0, 100, 200 and 300 mg/L. The effect of berberine hydrochloride on the survival rate and gut microbiota of C. japonica was investigated. Berberine hydrochloride improved the stability of the intestinal flora, with an increase in the abundance of probiotic species and a decrease in the abundance of both pathogenic bacteria after treatment with high concentrations of berberine hydrochloride. Berberine hydrochloride altered peroxidase activity (POD), malondialdehyde (MDA), and lipid peroxidation (LPO) in the intestinal tract compared to the control. Berberine hydrochloride could modulate the energy released from the enzyme activities of hexokinase (HK), phosphofructokinase (PFK), and pyruvate kinase (PK) in the intestinal tract of C. japonica infected with A. hydrophila. Zona occludens 1 (ZO-1), Zinc finger E-box binding homeobox 1 (ZEB1), occludin and signal transducer, and activator of transcription5b (STAT5b) expression were also increased, which improved intestinal barrier function. The results of this study provide new insights into the role of berberine hydrochloride in intestinal immune mechanisms and oxidative stress in crustaceans.

Indexed as

Aeromonas hydrophilaAntioxidantsBerberineGastrointestinal MicrobiomeGram-Negative Bacterial InfectionsAnimalsBacteriaBrachyuraLipid PeroxidationMalondialdehydeAntioxidantsBerberineMalondialdehyde16S rRNAAeromonas hydrophilaBerberine hydrochlorideCharybdis japonicaIntestinal microbes

Identifiers

PMID39095728
PMCPMC11295712

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.