Evidence map›Paper›PMID 39095633›Full record

SynthesisBreast cancer research and treatment2024

Influence of tumour grade on disease survival in male breast cancer patients: a systematic review.

Stephen Kinsey-Trotman, Alain Nguyen, Suzanne Edwards, Adam Swalling, Pallave Dasari, David Walsh, Wendy V Ingman

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephen Kinsey-TrotmanDiscipline of Surgical Specialties, Adelaide Medical School, The Queen Elizabeth Hospital, University of Adelaide, 28 Woodville Road DX465702, Woodville South, SA, 5011, Australia.
Alain NguyenLyell McEwin Hospital, Northern Adelaide Local Health Network, Haydown Rd, Elizabeth Vale, SA, 5112, Australia.
Suzanne EdwardsSchool of Public Health, University of Adelaide, Adelaide, SA, 5005, Australia.
Adam SwallingCentral Adelaide Local Health Network, 28 Woodville Rd, Woodville South, SA, 5011, Australia.
Pallave DasariDiscipline of Surgical Specialties, Adelaide Medical School, The Queen Elizabeth Hospital, University of Adelaide, 28 Woodville Road DX465702, Woodville South, SA, 5011, Australia.
David WalshDiscipline of Surgical Specialties, Adelaide Medical School, The Queen Elizabeth Hospital, University of Adelaide, 28 Woodville Road DX465702, Woodville South, SA, 5011, Australia.
Wendy V IngmanDiscipline of Surgical Specialties, Adelaide Medical School, The Queen Elizabeth Hospital, University of Adelaide, 28 Woodville Road DX465702, Woodville South, SA, 5011, Australia. wendy.ingman@adelaide.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHistological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS) in male breast cancer patients undergoing surgery.

methodsMEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival.

resultsA total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies.

conclusionsThis study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease.

Indexed as

Breast Neoplasms, MaleNeoplasm GradingHumansMaleNeoplasm Recurrence, LocalPrognosisMale breast cancerPrognostic biomarkerSurvivalTumour grade

Identifiers

PMID39095633
PMCPMC11452471

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.