ArticleDrugs in R&D2024
Pharmacokinetics, Tolerability, and Safety of Esmethadone in Subjects with Chronic Kidney Disease or Hepatic Impairment.
Article in Drugs in R&D, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment.Discover mental health · 2025Review
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesEsmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is a low potency N-methyl-
methodsHere we studied the pharmacokinetics and safety of esmethadone after a single oral dose of 25 mg in subjects with different stages of kidney and liver impairment.
resultsIn subjects with a mild and moderate decrease in glomerular fraction rate (GFR), esmethadone C
conclusionMild and moderate hepatic impairment has a minimal to modest impact on exposure to total or unbound esmethadone and dose adjustments are not warranted in subjects with mild and moderate hepatic impairment. Administration of esmethadone was well tolerated in healthy adult subjects, in subjects with mild or moderate hepatic impairment, and in subjects with mild moderate or severe renal impairment, including patients with ESRF undergoing dialysis.
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