ArticleNature communications2024
The lactonase BxdA mediates metabolic specialisation of maize root bacteria to benzoxazinoids.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Challenges and Future Directives of Synthetic Biology in Engineering Plant-Microbe Partnerships for Sustainable Agriculture.Biotechnology and bioengineering · 2026Review
- Evolutionary divergence and regulatory landscapes of benzoxazinoid metabolism in monocot crops.Plant cell reports · 2026Review
- Non-volatile plant metabolites as chemical signals: linking resilience to ecological sustainability under climate change.Plant cell reports · 2026Article
- Engineering Plant-Associated Soil Microbiomes for Sustainable and Climate-Resilient Agriculture: Mechanisms, Technologies, and Applications.Microorganisms · 2026Review
- Horizontal acquisition of nicotine catabolism gene cluster enhances Arthrobacter fitness within tobacco root microbiota.Microbiome · 2026Article
- Customizable High-Throughput Chemical Phenotyping of Root Bacteria.Bio-protocol · 2026Article
- Benzoxazinoid-mediated microbiome feedbacks enhance Arabidopsis growth and defence.The New phytologist · 2026Article
- Specialized Metabolic Reprogramming in Plant Immunity: Biosynthetic Networks, Spatiotemporal Regulation, and Quantitative Defense.Plants (Basel, Switzerland) · 2026Review
- mGem: Applying microbiome therapeutic learnings to next-generation agricultural bioproducts.mBio · 2026Review
- Rhizobacteria opportunistically boost colonization and impair plant fitness by degrading plant-derived coumarins under iron deficiency.Nature communications · 2026Article
- Root-knot nematode Meloidogyne incognita uses secondary-metabolite-mediated soil microbiome shifts to locate host plants.Nature plants · 2026Article
- Effects of cover cropping on orchard soil microbiomes: Mechanisms and perspectives.AIMS microbiology · 2026Review
- Article
- Effects of Native or Exogenous Benzoxazinoids on In Vitro Ruminal Fermentation and Degradability of Either Fresh or Ensiled Whole-Crop Maize-Based Diets in Cattle.Journal of animal physiology and animal nutrition · 2025Article
- Genetic architecture of resistance to plant secondary metabolites in Photorhabdus entomopathogenic bacteria.BMC genomics · 2025Article
- Synthetic communities of maize root bacteria interact and redirect benzoxazinoid metabolization.mSphere · 2025Article
- Alkaloids as mediators in plant-microbe interactions: Metabolism and role in the rhizosphere.Plant biotechnology (Tokyo, Japan) · 2025Article
- The chemical interaction between plants and the rhizosphere microbiome.Trends in plant science · 2025Review
- Roots: metabolic architects of beneficial microbiome assembly.Plant physiology · 2025Review
- Photosynthate distribution determines spatial patterns in the rhizosphere microbiota of the maize root system.Nature communications · 2025Article
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20 authors.
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Abstract
Root exudates contain specialised metabolites that shape the plant's root microbiome. How host-specific microbes cope with these bioactive compounds, and how this ability affects root microbiomes, remains largely unknown. We investigated how maize root bacteria metabolise benzoxazinoids, the main specialised metabolites of maize. Diverse and abundant bacteria metabolised the major compound in the maize rhizosphere MBOA (6-methoxybenzoxazolin-2(3H)-one) and formed AMPO (2-amino-7-methoxy-phenoxazin-3-one). AMPO forming bacteria were enriched in the rhizosphere of benzoxazinoid-producing maize and could use MBOA as carbon source. We identified a gene cluster associated with AMPO formation in microbacteria. The first gene in this cluster, bxdA encodes a lactonase that converts MBOA to AMPO in vitro. A deletion mutant of the homologous bxdA genes in the genus Sphingobium, did not form AMPO nor was it able to use MBOA as a carbon source. BxdA was identified in different genera of maize root bacteria. Here we show that plant-specialised metabolites select for metabolisation-competent root bacteria. BxdA represents a benzoxazinoid metabolisation gene whose carriers successfully colonize the maize rhizosphere and thereby shape the plant's chemical environmental footprint.
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