ArticleTranslational psychiatry2024
The role of functional emotion circuits in distinct dimensions of psychopathology in youth.
Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sex Differences in the Interaction of Epigenetic Risk and Trajectories of Default Mode Limbic Network Integration Predicting Childhood Anxiety.Research square · 2026Article
- A biopsychosocial approach to sleep health during puberty: Individual and contextual aspects and the role of gender differences. A narrative review.Cogent mental health · 2025Review
- Associations between parental psychopathology and youth functional emotion regulation brain networks.Developmental cognitive neuroscience · 2024Article
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Authors and funding
13 authors.
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Abstract
Several mental disorders emerge during childhood or adolescence and are often characterized by socioemotional difficulties, including alterations in emotion perception. Emotional facial expressions are processed in discrete functional brain modules whose connectivity patterns encode emotion categories, but the involvement of these neural circuits in psychopathology in youth is poorly understood. This study examined the associations between activation and functional connectivity patterns in emotion circuits and psychopathology during development. We used task-based fMRI data from the Philadelphia Neurodevelopmental Cohort (PNC, N = 1221, 8-23 years) and conducted generalized psycho-physiological interaction (gPPI) analyses. Measures of psychopathology were derived from an independent component analysis of questionnaire data. The results showed positive associations between identifying fearful, sad, and angry faces and depressive symptoms, and a negative relationship between sadness recognition and positive psychosis symptoms. We found a positive main effect of depressive symptoms on BOLD activation in regions overlapping with the default mode network, while individuals reporting higher levels of norm-violating behavior exhibited emotion-specific lower functional connectivity within regions of the salience network and between modules that overlapped with the salience and default mode network. Our findings illustrate the relevance of functional connectivity patterns underlying emotion processing for behavioral problems in children and adolescents.
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