Evidence map›Paper›PMID 39095013›Full record

Trial reportContemporary clinical trials2024

Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial.

Michelle W Voss, Chris Oehler, Will Daniels, Matthew Sodoma, Bryan Madero, James Kent, Shivangi Jain, Myungjin Jung, Virginia R Nuckols, Lyndsey E DuBose and 16 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Michelle W VossDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: michelle-voss@uiowa.edu.
Chris OehlerDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Will DanielsDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Matthew SodomaDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Bryan MaderoDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
James KentDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Shivangi JainDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Myungjin JungDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Virginia R NuckolsDepartment of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA.
Lyndsey E DuBoseDepartment of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA.
Kristen G DavisDepartment of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA.
Abby O'DeenDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Chase HamiltonDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Kelsey BallerDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA.
Jenna SpringerDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Department of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA.
Adriana Rivera-DompencielDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Marco PipolyDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Michael MuellerleileDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Nagalakshmi NagarajanDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Thorarinn BjarnasonDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Nidal HarbDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Li-Chun LinIowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Neuroscience and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Vincent MagnottaDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, USA; Iowa Neuroscience Institute, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Eliot HazeltineDepartment of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USA; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Jeffrey D LongDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, USA; Department of Biostatistics, College of Public Health, The University of Iowa, USA.
Gary L PierceDepartment of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa, USA; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Funding

Exercise to improve hippocampal connectivity and learning in older adultsR01AG055500 · NIA · UNIVERSITY OF IOWA · PI VOSS, MICHELLE WEBB · 2017 to 2021
$3.5M
University of Iowa - Research 3T MRI Connectome UpgradeS10OD025025 · OD · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2018 to 2018
$1.9M
Mechanisms of Health and Disease at the Behavioral-Biomedical InterfaceT32GM108540 · NIGMS · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K, VOSS, MICHELLE WEBB · 2014 to 2023
$1.7M
NIA NIH HHS R01 AG055500NIGMS NIH HHS T32 GM108540NIH HHS S10 OD025025
6 · The paper itself

Abstract

Despite evidence that aerobic exercise benefits the aging brain, in particular the hippocampus and memory, controlled clinical trials have not comprehensively evaluated effects of aerobic exercise training on human memory in older adults. The central goal of this study was to determine chronic effects of moderate-to-vigorous intensity aerobic exercise on the hippocampus and memory in non-demented, inactive adults ages 55-80 years. We determine effects of aerobic exercise training with a 6-month randomized controlled trial (RCT) comparing 150 min/week of home-based, light intensity exercise with progressive moderate-to-vigorous intensity aerobic exercise. For the first time in a large trial, we examined temporal mechanisms by determining if individual differences in the rapid, immediate effects of moderate intensity exercise on hippocampal-cortical connectivity predict chronic training-related changes over months in connectivity and memory. We examined physiological mechanisms by testing the extent to which chronic training-related changes in cardiorespiratory fitness are a critical factor to memory benefits. The Exercise Effects on Brain Connectivity and Learning from Minutes to Months (Brain-EXTEND) trial is conceptually innovative with advanced measures of hippocampal-dependent learning and memory processes combined with novel capture of the physiological changes, genetic components, and molecular changes induced by aerobic exercise that change hippocampal-cortical connectivity. Given that hippocampal connectivity deteriorates with Alzheimer's and aerobic exercise may contribute to reduced risk of Alzheimer's, our results could lead to an understanding of the physiological mechanisms and moderators by which aerobic exercise reduces risk of this devastating and costly disease.

Indexed as

Cardiorespiratory FitnessExerciseHippocampusAgedAged, 80 and overBrainFemaleHumansLearningMagnetic Resonance ImagingMaleMemoryMiddle AgedAerobic exerciseBlood biomarkersBrainCardiorespiratory fitnessCognitive agingLearning and memoryPhysical activity

Identifiers

PMID39095013
PMCPMC11438497

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.