Evidence map›Paper›PMID 39094954›Full record

ArticleBehavioural brain research2024

Early-life risperidone alters locomotor responses to apomorphine and quinpirole in adulthood.

Mark E Bardgett, Molly S Griffith, Kathleen R Robinson, Rachel M Stevens, Matthew A Gannon, Meghan D Knuth, Gregory S Hawk, James R Pauly

Abstract read
In one paragraph

Article in Behavioural brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark E BardgettDepartment of Psychological Science, Northern Kentucky University, Highland Heights, KY 41076, United States. Electronic address: bardgettm@nku.edu.
Molly S GriffithDepartment of Psychological Science, Northern Kentucky University, Highland Heights, KY 41076, United States.
Kathleen R RobinsonDepartment of Psychological Science, Northern Kentucky University, Highland Heights, KY 41076, United States.
Rachel M StevensDepartment of Psychological Science, Northern Kentucky University, Highland Heights, KY 41076, United States.
Matthew A GannonDepartment of Psychological Science, Northern Kentucky University, Highland Heights, KY 41076, United States.
Meghan D KnuthDepartment of Psychological Science, Northern Kentucky University, Highland Heights, KY 41076, United States.
Gregory S HawkDepartment of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY 40504, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40504, United States.
James R PaulyDepartment of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY 40504, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40504, United States.

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
ZEBRAFISH VISUAL FUNCTION RECOVERY FOLLOWING OPTIC NERVE DAMAGEP20RR016481 · NCRR · UNIVERSITY OF LOUISVILLE · PI COOPER, NIGEL G.F. · 2001 to 2011
$34.8M
Brain Development after Early-Life Antipsychotic TreatmentR16GM149498 · NIGMS · NORTHERN KENTUCKY UNIVERSITY · PI MARK Edward BARDGETT · 2023 to 2026
$548k
Long-term effects early-life antipsychotic drug treatmentR15DA041708 · NIDA · NORTHERN KENTUCKY UNIVERSITY · PI BARDGETT, MARK EDWARD · 2016 to 2016
$398k
NCRR NIH HHS P20 RR016481NIDA NIH HHS R15 DA041708NIGMS NIH HHS P20 GM103436NIGMS NIH HHS R16 GM149498
6 · The paper itself

Abstract

An escalating trend of antipsychotic drug use in children with ADHD, disruptive behavior disorder, or mood disorders has raised concerns about the impact of these drugs on brain development. Since antipsychotics chiefly target dopamine receptors, it is important to assay the function of these receptors after early-life antipsychotic administration. Using rats as a model, we examined the effects of early-life risperidone, the most prescribed antipsychotic drug in children, on locomotor responses to the dopamine D

Indexed as

Antipsychotic AgentsApomorphineDopamine AgonistsMotor ActivityQuinpiroleRats, Long-EvansRisperidoneAge FactorsAnimalsAnimals, NewbornDose-Response Relationship, DrugFemaleMaleRatsReceptors, Dopamine D2Sex FactorsAntipsychotic AgentsApomorphineDopamine AgonistsQuinpiroleReceptors, Dopamine D2RisperidoneAntipsychoticD2 receptorDevelopmentDopamineSex differenceSupersensitivity

Identifiers

PMID39094954
PMCPMC11345744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.