Evidence map›Paper›PMID 39094820›Full record

ArticleNeuroscience2024

Progressive long-term synaptic depression at cortical inputs into the amygdala.

Dimitrios Psyrakis, Julia Jasiewicz, Michael Wehrmeister, Kathrin Bonni, Beat Lutz, Sodikdjon A Kodirov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dimitrios PsyrakisInstitute of Physiological Chemistry and Pathobiochemistry, University Medical Center Mainz, Mainz, Germany.
Julia JasiewiczInstitute of Physiological Chemistry and Pathobiochemistry, University Medical Center Mainz, Mainz, Germany.
Michael WehrmeisterInstitute of Physiological Chemistry and Pathobiochemistry, University Medical Center Mainz, Mainz, Germany.
Kathrin BonniInstitute of Physiological Chemistry and Pathobiochemistry, University Medical Center Mainz, Mainz, Germany.
Beat LutzInstitute of Physiological Chemistry and Pathobiochemistry, University Medical Center Mainz, Mainz, Germany.
Sodikdjon A KodirovInstitute of Physiological Chemistry and Pathobiochemistry, University Medical Center Mainz, Mainz, Germany; Center for Biomedical Studies, Department of Biological Sciences, University of Texas at Brownsville, TX 78520, USA; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; Institute of Biophysics, Johannes Kepler University, Linz, Austria. Electronic address: Sodikdjon.Kodirov@jku.at.

Funding

Pathophysiology of the septo-hippocampal glutamatergic systemSC1NS065386 · NINDS · UNIV/TEXAS BROWNSVILLE & SOUTHMOST COLL · PI COLOM, LUIS V. · 2008 to 2011
$1.5M
NINDS NIH HHS SC1 NS065386
6 · The paper itself

Abstract

The convergence of conditioned and unconditioned stimuli (CS and US) into the lateral amygdala (LA) serves as a substrate for an adequate fear response in vivo. This well-known Pavlovian paradigm modulates the synaptic plasticity of neurons, as can be proved by the long-term potentiation (LTP) phenomenon in vitro. Although there is an increasing body of evidence for the existence of LTP in the amygdala, only a few studies were able to show a reliable long-term depression (LTD) of excitation in this structure. We have used coronal brain slices and conducted patch-clamp recordings in pyramidal neurons of the lateral amygdala (LA). After obtaining a stable baseline excitatory postsynaptic current (EPSC) response at a holding potential of -70 mV, we employed a paired-pulse paradigm at 1 Hz at the same membrane potential and could observe a reliable LTD. The different durations of stimulation (ranging between 1.5-24 min) were tested first in the same neuron, but the intensity was kept constant. The latter paradigm resulted in a step-wise LTD with a gradually increasing magnitude under these conditions.

Indexed as

AmygdalaExcitatory Postsynaptic PotentialsLong-Term Synaptic DepressionPatch-Clamp TechniquesAnimalsCerebral CortexElectric StimulationIn Vitro TechniquesMaleNeural PathwaysPyramidal CellsRatsRats, WistarAction potentialFear circuitLong-term synaptic plasticityPatch-clampSpike

Identifiers

PMID39094820
PMCPMC11709117

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.