Evidence map›Paper›PMID 39094678›Full record

ArticleResuscitation2024

Prospective evaluation of the relationship between cognition and recovery outcomes after cardiac arrest.

Erik Blennow Nordström, Jeffrey L Birk, Danielle A Rojas, Tara St Onge Sheehy, Camila I Domínguez-Imbert Nieto, Gaspar J Cruz, Maia Ten Brink, William Vargas, Maria Karas, Sachin Agarwal

Abstract read
In one paragraph

Article in Resuscitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erik Blennow NordströmColumbia University Irving Medical Center, Department of Neurology, New York, NY, United States; Lund University, Department of Clinical Sciences Lund, Neurology, Lund, Sweden; Skane University Hospital, Department of Rehabilitation Medicine, Lund, Sweden.
Jeffrey L BirkColumbia University Irving Medical Center, Center for Behavioral Cardiovascular Health, Department of Medicine, New York, NY, United States.
Danielle A RojasColumbia University Irving Medical Center, Department of Neurology, New York, NY, United States.
Tara St Onge SheehyColumbia University Irving Medical Center, Center for Behavioral Cardiovascular Health, Department of Medicine, New York, NY, United States.
Camila I Domínguez-Imbert NietoColumbia University Irving Medical Center, Center for Behavioral Cardiovascular Health, Department of Medicine, New York, NY, United States.
Gaspar J CruzColumbia University Irving Medical Center, Center for Behavioral Cardiovascular Health, Department of Medicine, New York, NY, United States.
Maia Ten BrinkColumbia University Irving Medical Center, Center for Behavioral Cardiovascular Health, Department of Medicine, New York, NY, United States.
William VargasColumbia University Irving Medical Center, Center for Behavioral Cardiovascular Health, Department of Medicine, New York, NY, United States.
Maria KarasWeill Cornell Medical Center, Division of Cardiology, New York, NY, United States.
Sachin AgarwalColumbia University Irving Medical Center, Department of Neurology, New York, NY, United States. Electronic address: sa2512@columbia.edu.

Funding

Patterns of Survivors' Recovery Trajectories in the ICECAP Trial (POST-ICECAP)R01NS127959 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sachin Agarwal, Clifton W. Callaway · 2023 to 2026
$7.1M
Positive and Negative Psychological Predictors of Long-Term Recovery after Cardiac ArrestR01HL151850 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIRK, JEFFREY LEE · 2021 to 2025
$3.8M
Characterize psychological and behavioral dimensions of cardiac arrest survivorship, and their association with 1-year mortality, cardiovascular disease risk, and health-related quality of lifeR01HL153311 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGARWAL, SACHIN · 2021 to 2024
$3.1M
NHLBI NIH HHS R01 HL151850NHLBI NIH HHS R01 HL153311NINDS NIH HHS R01 NS127959
6 · The paper itself

Abstract

purposeCognitive function is often impaired for cardiac arrest (CA) survivors due to hypoxic-ischemic brain injury. Whether cognitive impairment at hospital discharge is associated with recovery defined as functional status and fatigue measured at 1-month post-discharge is not known.

methodsConsecutive CA patients admitted at an academic center (May 14, 2021-June 23, 2023) were assessed for cognitive impairment (modified Telephone Interview for Cognitive Status, TICS-m < 33) and depressive symptoms (8-item Patient Health Questionnaire) at hospital discharge. Poor functional status (primary outcome; modified Rankin Scale, mRS > 3) and fatigue severity (patient-reported outcome; Modified Fatigue Impact Scale) were assessed 1-month post-discharge. Hierarchical regressions tested associations of cognitive function with outcomes.

resultsOf 112 participants (mean age 54.4 ± 14.8; 38% female; 43% White race, 20% Black race, 29% Hispanic ethnicity) completing discharge TICS-m, 63 (56%) had indicated cognitive impairment, and 68 (61%) had poor 1-month functional outcome. Worse discharge cognitive function was independently associated with a higher risk of poor 1-month functional outcome (OR = 0.88, 95% CI [0.79, 0.98], p = 0.02) after adjusting for age, education, sex, race, ethnicity, length of hospital stay, comorbidities, and depressive symptoms. Fatigue severity lacked significant associations with cognitive function, but was associated with depressive symptoms (B = 1.03 [0.00, 2.05], p = 0.04).

conclusionCognitive function at discharge after CA was significantly and independently associated with functional outcome 1 month after hospital discharge. Psychological distress contributed to fatigue severity. This highlights the need for screening and addressing cognitive and emotional problems pre-hospital discharge.

Indexed as

Cognitive DysfunctionHeart ArrestRecovery of FunctionAdultAgedCognitionDepressionFatigueFemaleFunctional StatusHumansMaleMiddle AgedPatient DischargeProspective StudiesCardiac arrestCognitive impairmentFatigueFunctional recoveryOutcomePsychological distress

Identifiers

PMID39094678
PMCPMC11390308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.