Evidence map›Paper›PMID 39094568›Full record

ArticleCell2024

Activation of the helper NRC4 immune receptor forms a hexameric resistosome.

Furong Liu, Zhenlin Yang, Chao Wang, Zhang You, Raoul Martin, Wenjie Qiao, Jian Huang, Pierre Jacob, Jeffery L Dangl, Jan E Carette and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026
    Review
  5. Article
  6. Review
  7. Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026
    Review
  8. Article
  9. Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026
    Review
  14. Review
  15. Article
  16. Review
  17. Subcellular calcium dynamics and organelle perturbations in resistosome-mediated cell death.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Review
  19. The transformative power of structural predictions with AI in plant science.The Plant journal : for cell and molecular biology · 2026
    Review
  20. Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Furong LiuDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Zhenlin YangCalifornia Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: zhenlinyang@berkeley.edu.
Chao WangDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Zhang YouDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Raoul MartinInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Wenjie QiaoDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Jian HuangDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Pierre JacobDepartment of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jeffery L DanglDepartment of Biology and Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jan E CaretteDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Sheng LuanDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Eva NogalesCalifornia Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Molecular Biophysics and Integrative Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Brian J StaskawiczDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: stask@berkeley.edu.

Funding

Calcium coding mechanisms in plant cell growth and immunityR01GM138401 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LUAN, SHENG · 2020 to 2023
$1.7M
NIGMS NIH HHS R01 GM138401
6 · The paper itself

Abstract

Innate immune responses to microbial pathogens are regulated by intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) in both the plant and animal kingdoms. Across plant innate immune systems, "helper" NLRs (hNLRs) work in coordination with "sensor" NLRs (sNLRs) to modulate disease resistance signaling pathways. Activation mechanisms of hNLRs based on structures are unknown. Our research reveals that the hNLR, known as NLR required for cell death 4 (NRC4), assembles into a hexameric resistosome upon activation by the sNLR Bs2 and the pathogenic effector AvrBs2. This conformational change triggers immune responses by facilitating the influx of calcium ions (Ca

Indexed as

ArabidopsisArabidopsis ProteinsCalciumDisease ResistanceImmunity, InnateNLR ProteinsPlant ImmunityReceptors, ImmunologicArabidopsis ProteinsCalciumNLR ProteinsReceptors, Immunologiccalcium influxETINLR proteinsNRC0NRC2NRC3NRC4 resistosomepathogen recognitionplant immunityPTI

Identifiers

PMID39094568
PMCPMC11380581

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.