ArticleThe journal of nutrition, health & aging2024
Serum Uric Acid Levels Associated with Outcomes of Neurodegenerative Disorders and Brain Health: Findings from the UK Biobank.
Article in The journal of nutrition, health & aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Longitudinal serum uric acid levels are not associated with dopamine transporter binding in progressive supranuclear palsy.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Serum uric acid levels and longitudinal change in cognitive function in older adults: a sex-stratified population-based study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms.World journal of gastrointestinal oncology · 2025Article
- Aggression and Justice Involvement: Does Uric Acid Play a Role?Brain sciences · 2025Article
- Comparative characteristics of homocysteine and uric acid in patients with Parkinson's disease-related cognitive impairment and post-stroke cognitive impairment.Frontiers in neurologyArticle
- Associations between serum uric acid levels and risk of dementia in community-dwelling older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- U-shaped association between serum uric acid at admission and post-stroke epilepsy in patients with ischemic stroke: a cohort study.Frontiers in neurologyArticle
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13 authors.
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Abstract
backgroundThe relationship between serum uric acid (SUA) levels and brain-related health remains uncertain.
objectivesThis study aimed to investigate the relationship between SUA levels and some neurodegenerative disorders and brain structure.
designA longitudinal study. SETTING AND
participants384,517 participants who did not have stroke, dementia, and Parkinsonism, with complete urate testes and covariates were included. MEASUREMENTS: Cox proportional hazards models, competing risk models, and restricted cubic spine models were applied.
resultsDuring the median follow-up time of 12.7 years (interquartile range [IQR]:12.0, 13.5), 7821 (2.0%) participants developed stroke, 5103 (1.3%) participants developed dementia, and 2341 (0.6%) participants developed Parkinsonism. Nonlinear relationships were identified between SUA levels and stroke (J-shaped), dementia, and Parkinsonism (U-shaped). SUA levels of 4.2 mg/dl, 6.4 mg/dl, and 6.6 mg/dl yielded the lowest risk of stroke, dementia, and Parkinsonism, respectively. Besides, we found high SUA levels reduced the volumes of total brain, grey matter, white matter, grey matter in the hippocampus, and hippocampus, but increased lateral-ventricle volume. Inflammation accounted for 9.1% and 10.0% in the association of SUA with stroke and lateral-ventricle volume.
conclusionsLower SUA levels increased the risk of Parkinsonism, while both lower and higher SUA levels were positively associated with increased risk of stroke and dementia. Moreover, high SUA levels reduced brain structure volumes. Our findings suggest the association between SUA levels and brain-related disorders and highlight the importance of SUA management.
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