Evidence map›Paper›PMID 39094065›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024

Durability of Response With Selpercatinib in Patients With

Lori J Wirth, Marcia S Brose, Vivek Subbiah, Francis Worden, Ben Solomon, Bruce Robinson, Julien Hadoux, Pascale Tomasini, Daniela Weiler, Barbara Deschler-Baier and 7 more

Abstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. SEOM-GETNE-TTCC Clinical guideline thyroid cancer (2023).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Guideline
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  4. Review
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  18. Review
  19. Redefining thyroid cancer management.Nature reviews. Endocrinology · 2025
    Article
  20. AdvancingTranslational cancer research · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Lori J WirthMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-2629-2289
Marcia S BroseUniversity of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-7096-4057
Vivek SubbiahUniversity of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-6064-6837
Francis WordenRogel Cancer Center, University of Michigan, Ann Arbor, MI.
Ben SolomonPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0003-3059-5730
Bruce RobinsonRoyal North Shore Hospital, St Leonards, NSW, Australia.
Julien HadouxService d'Oncologie Endocrinienne, Gustave Roussy, Villejuif, France.ORCID 0000-0002-1276-3289
Pascale TomasiniAix-Marseille University, CNRS, INSERM, CRCM, APHM, CEPCM, Marseille, France.
Daniela WeilerCantonal Hospital, Luzern, Switzerland.ORCID 0009-0007-8059-7861
Barbara Deschler-BaierUniversity of Würzburg Comprehensive Cancer Centre, Würzburg, Germany.
Daniel S W TanNational Cancer Centre Singapore, Singapore.ORCID 0000-0002-6514-6786
Patricia MaedaEli Lilly and Company, Indianapolis, IN.ORCID 0000-0002-3377-5705
Yan LinEli Lilly and Company, Indianapolis, IN.
Ravinder SinghEli Lilly and Company, Indianapolis, IN.ORCID 0009-0001-6484-1365
Theresa BaytEli Lilly and Company, Indianapolis, IN.
Alexander DrilonMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.ORCID 0000-0001-6806-9061
Philippe A CassierCentre Léon Bérard, Medical Oncology, Lyon, France.ORCID 0000-0003-3857-1688

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Integration of Imaging and Circulating Plasma Cell-Free DNA Sequencing Using MSK-ACCESS to Monitor Treatment Response and Predict Progression in Patients With Multiple Cancers on Targeted TherapyR01CA273224 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Michael F. Berger, Alexander Drilon · 2022 to 2026
$3.6M
Predicting sensitivity and resistance in RET-driven cancersR01CA251591 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DRILON, ALEXANDER · 2021 to 2025
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA251591NCI NIH HHS R01 CA273224
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Proto-Oncogene Proteins c-retPyrazolesPyridinesThyroid NeoplasmsAdultAgedAged, 80 and overAnilidesCarcinoma, NeuroendocrineFemaleHumansMaleMiddle AgedMutationProgression-Free SurvivalProtein Kinase InhibitorsAnilidescabozantinibProtein Kinase InhibitorsProto-Oncogene Proteins c-retPyrazolesPyridinesRET protein, humanselpercatinib

Identifiers

PMID39094065
PMCPMC11404750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.