Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Dharaniya SakthivelDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3632-1688
Alexandra N Brown-SuedelDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Karla E LopezDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Suruchi SalgarDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-0762-3051
Luiza E CoutinhoDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Francesca KeaneDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Shixia HuangAdvanced Technology Cores, Department of Molecular and Cellular Biology, Huffington Department of Education, Innovation & Technology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2878-4129
Kenneth Mc SherryDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0000-6904-048X
Chloé I CharendoffDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0007-1980-3822
Kevin P DunneDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0003-0393-8037
Dexter J RobichauxDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-4807-459X
Alexander Vargas-HernándezDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8409-4862
BaoChau LeTexas Children's Hospital William T. Shearer Center for Human Immunobiology, Houston, TX 77030, USA.
Crystal S ShinMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Alexandre F CariseyDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.ORCID 0000-0003-1326-2205
Marcin PorebaDepartment of Chemical Biology and Bioimaging, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw 50370, Poland.
Jonathan M FlanaganDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-1330-6618
Lisa Bouchier-HayesDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-3886-5977
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Hematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3M
Training Program in Cell and Molecular BiologyT32GM136560 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Rachel Nicole Arey, WEEI-CHIN LIN · 2020 to 2026
$3.9M
Non-apoptotic functions of caspase-2 in cell division and genomic stabilityR01GM121389 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BOUCHIER-HAYES, LISA · 2018 to 2022
$1.8M
Cardiovascular Research and Drug Development (CRDD) training programT32HL170967 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens, Damian Winston Young · 2024 to 2026
$830k
Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survivalR21CA256606 · NCI · BAYLOR COLLEGE OF MEDICINE · PI BOUCHIER-HAYES, LISA · 2021 to 2022
$422k
Quanterix 2470 Arrayer for Reverse Phase Protein Array TechnologyS10OD028648 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUANG, SHIXIA · 2020 to 2020
Mutation in nucleophosmin (NPM1) causes relocalization of this normally nucleolar protein to the cytoplasm (NPM1c+). Despite NPM1 mutation being the most common driver mutation in cytogenetically normal adult acute myeloid leukemia (AML), the mechanisms of NPM1c+-induced leukemogenesis remain unclear. Caspase-2 is a proapoptotic protein activated by NPM1 in the nucleolus. Here, we show that caspase-2 is also activated by NPM1c+ in the cytoplasm and DNA damage-induced apoptosis is caspase-2 dependent in
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia. · full record | OpenQuestion