ArticleScience advances2024
Dentate gyrus ensembles gate context-dependent neural states and memory retrieval.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Hippocampal engrams configure prefrontal context representations to guide flexible decisions.bioRxiv : the preprint server for biology · 2026Article
- The role of GABANeuroscience and biobehavioral reviews · 2026Review
- Distinct CA1 inputs support shifts in neural dimensionality and memory resolution.bioRxiv : the preprint server for biology · 2026Article
- Early intrinsic excitability plasticity of neocortical engram neurons defines memory formation and precision.Nature communications · 2025Article
- Sparse memory ensembles set brain-wide network states to sustain learned associations.iScience · 2025Article
- Propofol differentially modulates the consolidation of schema-related and -unrelated memory.iScience · 2025Article
- Memory Gate Controlled by Contexts: Potential Key Structure That Could Link Small Associative Failures With Severe Cognitive Disorders.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
- Cortico-subcortical networks that determine behavioral memory renewal are redefined by noradrenergic neuromodulation.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Memories of events are linked to the contexts in which they were encoded. This contextual linking ensures enhanced access to those memories that are most relevant to the context at hand, including specific associations that were previously learned in that context. This principle, referred to as encoding specificity, predicts that context-specific neural states should bias retrieval of particular associations over others, potentially allowing for the disambiguation of retrieval cues that may have multiple associations or meanings. Using a context-odor paired associate learning paradigm in mice, here, we show that chemogenetic manipulation of dentate gyrus ensembles corresponding to specific contexts reinstates context-specific neural states in downstream CA1 and biases retrieval toward context-specific associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.