ArticleACS nano2024
Ultrasensitive Surface-Enhanced Raman Scattering Platform for Protein Detection via Active Delivery to Nanogaps as a Hotspot.
Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Plasmonic Nanoarray Biosensors for Non-Invasive Cancer Diagnostics.Biosensors · 2026Review
- Electrolyte- and Hydrodynamics-Controlled Potentiostatic Growth of Ag Nanodendrites on Metallic Ti for SERS Detection.ACS omega · 2026Article
- Reconfigurable Nanogap SERS for Multiscale Molecular Sensing on Curved Surfaces.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Statistical quantification of SERS signals in microfluidic flow using AuNP-bound polystyrene microparticles.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Enhancing glyphosate detection in rice by SERS: controlled aggregation of silver nanoparticles and carbon disulfide-mediated signal amplification.Food chemistry: X · 2025Article
- Self-Assembled Three-Dimensional Au Films as Highly Reproducible and "Hotspots"-Rich Substrates for Multiplex SERS Detection.Analytical chemistry · 2025Article
- Versatile Nanoparticle Capsule Formation With Enhanced Encapsulation Efficiency via Solute-Induced Liquid-Liquid Phase Separation.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Alternating Binary Multilayers of Alkanethiol-Modified Gold Nanoparticles and Quantum Dots with Artificial Three-Dimensional Structures and Rational Photoluminescence.ACS applied materials & interfaces · 2025Article
- Fabricating a Three-Dimensional Surface-Enhanced Raman Scattering Substrate Using Hydrogel-Loaded Freeze-Induced Silver Nanoparticle Aggregates for the Highly Sensitive Detection of Organic Pollutants in Seawater.Sensors (Basel, Switzerland) · 2025Article
- Advances in Surface-Enhanced Raman Spectroscopy for Urinary Metabolite Analysis: Exploiting Noble Metal Nanohybrids.Biosensors · 2024Review
- Challenges and Prospects of Personalized Healthcare Based on Surface-Enhanced Raman Spectroscopy.Research (Washington, D.C.) · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Surface-enhanced Raman scattering (SERS) is an attractive technique in molecular detection with high sensitivity and label-free characteristics. However, its use in protein detection is limited by the large volume of proteins, hindering its approach to the narrow spaces of hotspots. In this study, we fabricated a Au nanoTriangle plate Array on Gel (AuTAG) as an SERS substrate by attaching a Au nanoTriangle plate (AuNT) arrangement on a thermoresponsive hydrogel surface. The AuTAG acts as an actively tunable plasmonic device, on which the interparticle distance is altered by controlling temperature via changes in hydrogel volume. Further, we designed a Gel Filter Trapping (GFT) method as an active protein delivery strategy based on the characteristics of hydrogels, which can absorb water and separate biopolymers through their three-dimensional (3D) polymer networks. On the AuTAGs, fabricated with AuNTs modified with charged surface ligands to prevent the nonspecific adsorption of analytes to particles, the GFT method helped the delivery of proteins to hotspot areas on the AuNT arrangement. This combination of a AuTAG substrate and the GFT method enables ultrahigh sensitivity for protein detection by SERS up to a single-molecule level as well as a wide quantification concentration range of 6 orders due to their geometric advantages.
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Registered trials
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