Evidence map›Paper›PMID 39093526›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2024

Blood culture bottles meet the operating room: enhancing the diagnostic accuracy of infectious spondylitis through open microsurgical biopsy and intraoperative inoculation.

Kyung Joon Kim, Dong Hwan Kim, Kyoung Hyup Nam, Byung Kwan Choi, Seungjin Lim, Jongyoun Yi, In Ho Han, Kye-Hyung Kim

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The biopsy dilemma in spinal infections: timing of antibiotics and diagnostic yield.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kyung Joon KimDepartment of Neurosurgery, Pusan National University School of Medicine, Busan, South Korea.
Dong Hwan KimDepartment of Neurosurgery, Pusan National University School of Medicine, Busan, South Korea.
Kyoung Hyup NamDepartment of Neurosurgery, Pusan National University School of Medicine, Busan, South Korea.
Byung Kwan ChoiDepartment of Neurosurgery, Pusan National University School of Medicine, Busan, South Korea.
Seungjin LimDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea.
Jongyoun YiMedical Research Institute, Pusan National University Hospital, Busan, South Korea.
In Ho Han *Department of Neurosurgery, Pusan National University School of Medicine, Busan, South Korea. farlateral@hanmail.net.
Kye-Hyung Kim *Medical Research Institute, Pusan National University Hospital, Busan, South Korea. kyehyungs@gmail.com.

Funding

Pusan National University 2-Year Research Grant
6 · The paper itself

Abstract

purposeInfectious spondylitis is caused by hematogenous seeding or adjacent soft tissue infection. No study has provided evidence that incubating biopsy specimens in blood culture bottles could enhance detection rates, nor has any study compared this method with conventional culture techniques. We aimed to assess the diagnostic yield of open microsurgical biopsies for infectious spondylitis and the efficacy of various culture media in the presence and absence of pre-biopsy antibiotic therapy.

methodsThis retrospective study, which was conducted at a university-affiliated teaching hospital in Korea, enrolled 165 adult patients with suspected infectious spondylitis between February 2014 and September 2020. The diagnostic yield of open biopsy was compared among three culture media, namely, blood culture bottles, swab culture using transport media, and tissue culture using plain tubes, while considering preoperative antibiotic exposure.

resultsCausative bacteria were identified in 84.2% of all cases. Blood culture bottles had the highest positivity rate (83.5%), followed by swab cultures (64.4%) and tissue cultures (44.9%). The differences in positivity rates were significant (P < 0.001). Preoperative antibiotic therapy reduced detection rates across all media, particularly in tissue cultures.

conclusionsWe established the high diagnostic yield of open microsurgical biopsy using blood culture bottles, suggesting that pre-biopsy antibiotic therapy significantly affects bacterial detection, thereby underscoring the importance of culture medium selection in the diagnosis of infectious spondylitis.

Indexed as

Blood CultureOperating RoomsSpondylitisAdultAgedAged, 80 and overAnti-Bacterial AgentsBacteriaBiopsyCulture MediaFemaleHumansMaleMicrosurgeryMiddle AgedRepublic of KoreaAnti-Bacterial AgentsCulture MediaBlood culture bottleInfectious spondylitisOpen biopsyPreoperative antibiotics

Identifiers

PMID39093526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.