Evidence map›Paper›PMID 39093484›Full record

ArticleArchives of dermatological research2024

Concurrent genotyping and expression of NLRP3 inflammasome in pityriasis versicolor patient's skin lesions.

Sara Kamal AbdelMaksoud Rizk, Azza Gaber, Hadir Hamdy, Azza Labeeb, Eman Fouda, Ammar Hosny, Sara A El Derbaly

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Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sara Kamal AbdelMaksoud RizkMedical Biochemistry and Molecular Biology Department, Faculty of medicine, Menoufia University, Shebin Elkom, Egypt. dr_sarakamal@yahoo.com.
Azza GaberDepartment of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Hadir HamdyDermatology and Andrology Department in Dekernes General Hospital, Dakahlia Governorate, el dakahleya, Egypt.
Azza LabeebMicrobiology and immunology Department, Faculty of medicine, Menoufia University, Shebin Elkom, Egypt.
Eman FoudaDepartment of Chemistry, Biochemistry Division, Faculty of Science, Menoufia University, Shebin Elkom, Egypt.
Ammar HosnyFaculty of Science, Al-Azhar University, Cairo, Egypt.
Sara A El DerbalyMedical Biochemistry and Molecular Biology Department, Faculty of medicine, Menoufia University, Shebin Elkom, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of this study is to investigate the impact of the rs35829419 SNP on the serum level of NLRP3, and to assess the relationship between NLRP3 and its SNP and vulnerability to Pityriasis versicolor. Pityriasis versicolor (PV) is one of the most frequent skin conditions linked to skin pigmentation changes. Malassezia plays a key role in the pathogenesis of PV. A case-control study, 50 patients with pityriasis versicolor and 44 healthy controls. Real-time PCR was used to genotype NLRP3 (rs35829419) and ELISA assay of NLRP3 levels in tissue samples. There was a significantly higher median NLPR3 levels in PV patients than controls. A significant predominance of A allele of Q 705 K was in patients than controls. The risk of having the disease in the presence of A allele is nearly 10 times than having C allele. In PV patients, there was a significant relationship between NLPR3 levels and Q 705 K genotypes with higher NLPR3 levels in AA genotype. A potential correlation between PV and the Q705K polymorphism, pointing to evidence of NLRP3 alteration in PV patients. The NLRP3 inflammasome may be an appropriate therapeutic target for Malassezia-associated skin disorders.

Indexed as

GenotypeInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinPolymorphism, Single NucleotideSkinTinea VersicolorAdolescentAdultAllelesCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansMalasseziaMaleMiddle AgedInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanELISANLRP3Pityriasis versicolorQ 705 KReal time-PCRrs35829419

Identifiers

PMID39093484

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.