ArticleClinical oral implants research2024
The systemic impact of non-surgical treatment of peri-implantitis with or without adjunctive systemic metronidazole: Secondary analysis of a randomized clinical trial.
Article in Clinical oral implants research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03564301 (Metronidazole as an Adjunct of Non- Surgical Treatment of Peri-implantitis), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metronidazole as an Adjunct of Non- Surgical Treatment of Peri-implantitis : a 6-months Placebo- Controlled Clinical Trial in Humans
Who cites it
4 citing papers in PubMed.
- Surgical Therapy for Peri-Implantitis Using Deproteinised Bovine Bone Mineral With 10% Collagen, Enamel Matrix Derivative and Doxycycline: A Prospective Cohort 10-Year Implant Study.Journal of clinical periodontology · 2026Article
- Clinical Severity, Pre- and Post-Explantation Cytokine Profile and SEM/EDX-Defined Corrosion-Related Findings in Advanced Peri-Implantitis: Preliminary Results from the PERI-EDU Prospective Exploratory Clinical Study.Journal of functional biomaterials · 2026Article
- Peri-implantitis: a systemic burden for our patients.Frontiers in dental medicine · 2026Review
- The systemic impact of non-surgical treatment of peri-implantitis with or without adjunctive systemic metronidazole: Secondary analysis of a randomized clinical trial.Clinical oral implants research · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesThe aim of this study was to evaluate the systemic effect of non-surgical peri-implantitis treatment (NSPIT) with or without the administration of systemic metronidazole.
methodsIn this secondary analysis from a previously published clinical trial (NCT03564301), peri-implantitis patients were randomized into two groups: test, receiving NSPIT plus 500 mg of oral systemic metronidazole three times a day for 7 days (n = 10); and control group, receiving NSPIT plus placebo (n = 11). Serum samples were obtained at baseline, 3 and 6 months after therapy to determine levels of inflammatory biomarkers, lipid fractions and complete blood counts.
resultsBoth treatment modalities produced improvements in clinical and radiographic parameters. After 6 months from NSPIT, a substantial reduction in C-reactive protein (6.9 mg/dL; 95% CI: 3.7 to 9.9, p < .001) and low-density lipoprotein cholesterol (21.8 mg/dL; 95% CI: -6.9 to 50.5, p = .013) as well as a modest increase in neutrophils counts (0.4 × 10
conclusionsNSPIT showed a short-term beneficial systemic effect regardless of adjunctive use of systemic metronidazole.
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