Evidence map›Paper›PMID 39093046›Full record

SynthesisBiomolecules & biomedicine2024

The severity of intrahepatic cholestasis of pregnancy and its association with pregnancy complications and neonatal asphyxia: A single-center case analysis and systematic review.

Siming Xin, Mengjiao Liu, Hua Lai, Liju Nie, Ying Hong, Yin Xiong, Xianxian Liu, Ting Wu, Xiaoming Zeng, Fen Fu

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biomolecules & biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siming XinDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
Mengjiao LiuSchool of Public Health, Nanchang University, Nanchang, China.
Hua LaiDepartment of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
Liju NieDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Department of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
Ying HongDepartment of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
Yin XiongDepartment of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
Xianxian LiuKey Laboratory of Women's Reproductive Health of Jiangxi Province, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
Ting WuSchool of Public Health, Nanchang University, Nanchang, China.
Xiaoming ZengDepartment of Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, China.
Fen FuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP) poses significant risks to maternal and neonatal health. Our study at Jiangxi Provincial Maternal and Child Health Hospital analyzed clinical and biochemical markers in singleton pregnancies diagnosed with ICP from October 2016 to December 2022. This research, supported by a systematic review and meta-analysis of existing studies, highlights the increasing incidence of ICP and its association with elevated levels of total bile acids, transaminases, and bilirubin. Our findings indicate a marked increase in the risk of preterm birth, cesarean delivery, and neonatal asphyxia as the severity of ICP escalates. This underscores the need for vigilant monitoring and management of affected pregnancies. By confirming the relationship between biochemical marker abnormalities and adverse pregnancy outcomes, our study advocates for enhanced clinical strategies and paves the way for future research aimed at improving prevention, diagnosis, and treatment methods for ICP.

Indexed as

Asphyxia NeonatorumCholestasis, IntrahepaticPregnancy ComplicationsAdultBile Acids and SaltsBilirubinBiomarkersCesarean SectionFemaleHumansInfant, NewbornPregnancyPregnancy OutcomePremature BirthSeverity of Illness IndexBile Acids and SaltsBilirubinBiomarkers

Identifiers

PMID39093046
PMCPMC11496850

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.