Evidence map›Paper›PMID 39093001›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Activation of IP

Emily C Akerman, Matthew J Read, Samuel J Bose, Andreas Koschinski, Rebecca A Capel, Ying-Chi Chao, Milda Folkmanaite, Thamali Ayagama, Steven D Broadbent, Rufaida Ahamed and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. 2-Aminoethoxydiphenyl borate induces arrhythmias via Cx43-S282 dephosphorylation.In vitro cellular & developmental biology. Animal · 2026
    Article
  2. Article
  3. Activation of IPAmerican journal of physiology. Heart and circulatory physiology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Emily C AkermanDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Matthew J ReadDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.ORCID 0009-0007-6767-2994
Samuel J BoseDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2922-3075
Andreas KoschinskiDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1876-3279
Rebecca A CapelDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7422-589X
Ying-Chi ChaoDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-5946-6196
Milda FolkmanaiteDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Thamali AyagamaDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Steven D BroadbentAxol Bioscience Limited, Cambridge, United Kingdom.ORCID 0000-0002-7872-3968
Rufaida AhamedAxol Bioscience Limited, Cambridge, United Kingdom.
Jillian N SimonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8140-7782
Derek A TerrarDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Manuela ZaccoloDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0934-3662
Rebecca A B BurtonDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0904-3862

Funding

British Heart Foundation (BHF) PG/18/4/33521British Heart Foundation (BHF) RG/17/6/32944Wellcome TrustWellcome Trust (WT) 109371/Z/15/Z
6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Excessive stimulation of the inositol (1,4,5)-trisphosphate (IP

Indexed as

Cyclic AMPCytosolFluorescence Resonance Energy TransferHeart AtriaInositol 1,4,5-Trisphosphate ReceptorsMyocytes, CardiacAnimalsAnimals, NewbornBoron CompoundsCalcium SignalingCells, CulturedInositol 1,4,5-TrisphosphatePhenylephrineRatsRats, Sprague-DawleySecond Messenger SystemsBoron CompoundsCyclic AMPInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsPhenylephrineadenylyl cyclaseCa2+ signalingcardiac atriacyclic AMPinositol trisphosphate

Identifiers

PMID39093001
PMCPMC11482242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.