Evidence map›Paper›PMID 39092977›Full record

ArticleBJS open2024

Japanese living donor liver transplantation criteria for hepatocellular carcinoma: nationwide cohort study.

Masahiro Ohira, Gaku Aoki, Yasushi Orihashi, Kenichi Yoshimura, Takeo Toshima, Etsuro Hatano, Susumu Eguchi, Taizo Hibi, Kiyoshi Hasegawa, Yuzo Umeda and 20 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BJS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Masahiro OhiraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Gaku AokiDepartment of Biostatistics, Clinical Research Centre in Hiroshima, Hiroshima University Hospital, Hiroshima, Japan.
Yasushi OrihashiDepartment of Biostatistics, Clinical Research Centre in Hiroshima, Hiroshima University Hospital, Hiroshima, Japan.
Kenichi YoshimuraMedical Centre for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
Takeo ToshimaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Etsuro HatanoDivision of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Susumu EguchiDepartment of Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Taizo HibiDepartment of Paediatric Surgery and Transplantation, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-6867-228X
Kiyoshi HasegawaDivision of Artificial Organ and Transplantation, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yuzo UmedaDepartment of Gastroenterological Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Takuya HashimotoDivision of Hepato-Biliary-Pancreatic and Transplantation Surgery, Japanese Red Cross Medical Centre, Tokyo, Japan.
Yasushi HasegawaDepartment of Surgery, School of Medicine, Keio University, Tokyo, Japan.ORCID 0000-0002-4990-0419
Shuji NoboriDepartment of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yasuhiro OguraDepartment of Transplantation Surgery, Nagoya University Hospital, Nagoya, Japan.
Hiroyuki NittaDepartment of Surgery, School of Medicine, Iwate Medical University, Yahaba, Japan.
Hiroto EgawaDepartment of Hepato-Biliary-Pancreatic Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.ORCID 0000-0002-2318-1129
Yasutsugu TakadaDepartment of Hepato-Biliary-Pancreatic and Breast Surgery, Graduate School of Medicine, Ehime University, Toon, Japan.
Yoshihide UedaDivision of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan.
Mureo KasaharaOrgan Transplantation Centre, National Centre for Child Health and Development, Tokyo, Japan.
Shigeyuki KawachiDepartment of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Centre, Tokyo, Japan.
Yuji SoejimaDivision of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation, and Paediatric Surgery, Department of Surgery, Shinshu University, Matsumoto, Japan.
Katsutoshi TokushigeDepartment of Internal Medicine, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Hiroaki NaganoDepartment of Gastroenterological, Breast, and Endocrine Surgery, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Hironori HagaDepartment of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Takumi FukumotoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan.
Satoshi MochidaDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Koji UmeshitaDepartment of Surgery, Osaka International Cancer Institute, Osaka, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0002-9066-1288
Japanese Liver Transplantation Society

Funding

Japan Agency for Medical Research and Development JP23fk0210108
6 · The paper itself

Abstract

backgroundValidating the expanded criteria for living donor liver transplantation for hepatocellular carcinoma using national data is highly significant. The aim of this study was to evaluate the validity of the new Japanese criteria for living donor liver transplantation for hepatocellular carcinoma patients and identify factors associated with a poor prognosis using the Japanese national data set.

methodsThe study population comprised patients who underwent living donor liver transplantation for hepatocellular carcinoma at 37 centres in Japan between 2010 and 2018. In a nationwide survey, the overall survival and recurrence-free survival rates were evaluated based on the new Japanese criteria for applying the 5-5-500 rule when extending the indication beyond the Milan criteria. Prognostic factors within the Japanese criteria were determined using the Cox proportional hazards model.

resultsPatients within (485 patients) and beyond (31 patients) the Japanese criteria exhibited 5-year overall survival rates of 81% and 58% and 5-year recurrence-free survival rates of 77% and 48% respectively. Patients who met the Milan criteria, but not the 5-5-500 rule, had poorer outcomes. Multivariate analysis for 474 patients identified a neutrophil-to-lymphocyte ratio greater than or equal to 5 and a history of hepatectomy as independent risk factors.

conclusionThis nationwide survey confirms the validity of the Japanese criteria. The poor prognostic factors within the Japanese criteria include a neutrophil-to-lymphocyte ratio greater than or equal to 5 and previous hepatectomy.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsLiver TransplantationLiving DonorsAdultAgedCohort StudiesDisease-Free SurvivalEast Asian PeopleFemaleHepatectomyHumansJapanMaleMiddle AgedPrognosis

Identifiers

PMID39092977
PMCPMC11295212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.